脱氢雌马酚
脱氢雌马酚结构式
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常用名 | 脱氢雌马酚 | 英文名 | Phenoxodiol |
|---|---|---|---|---|
| CAS号 | 81267-65-4 | 分子量 | 240.254 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 463.7±45.0 °C at 760 mmHg | |
| 分子式 | C15H12O3 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 234.3±28.7 °C | |
| 符号 |
GHS07, GHS09 |
信号词 | Warning |
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Involvement of a Hydrophobic Pocket and Helix 11 in Determining the Modes of Action of Prenylated Flavonoids and Isoflavonoids in the Human Estrogen Receptor.
ChemBioChem. 16 , 2668-77, (2016) Six prenylated (iso)flavonoids were purified from a licorice root extract and subjected to competition experiments with six commercially available (iso)flavonoids. The agonistic and antagonistic activities of these compounds towards both hERα (human estrogen ... |
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Enhancement of the activity of phenoxodiol by cisplatin in prostate cancer cells.
Br. J. Cancer 100 , 649-655, (2009) Phenoxodiol is a novel isoflav-3-ene, currently undergoing clinical trials, that has a broad in vitro activity against a number of human cancer cell lines. Phenoxodiol alone inhibited DU145 and PC3 in a dose- and time-dependent manner with IC(50) values of 8+... |
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Pharmacokinetics of phenoxodiol, a novel isoflavone, following intravenous administration to patients with advanced cancer.
BMC Clin. Pharmacol. 11 , 1, (2011) Phenoxodiol is a novel isoflavone currently being studied in clinical trials for the treatment of cancer. This study reports the pharmacokinetics of phenoxodiol in patients with cancer.The pharmacokinetics of phenoxodiol was studied following a single intrave... |
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The X-linked inhibitor of apoptosis protein (XIAP) is up-regulated in metastatic melanoma, and XIAP cleavage by Phenoxodiol is associated with Carboplatin sensitization.
J. Transl. Med. 5 , 6, (2007) XIAP up-regulation is associated with chemotherapy resistance. Phenoxodiol causes XIAP degradation and chemotherapy sensitization in ovarian cancer. Here we assessed XIAP expression in melanomas, using tissue microarrays containing 436 melanomas and 336 nevi ... |
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The effects of phenoxodiol on the cell cycle of prostate cancer cell lines.
Cancer Cell Int. 14(1) , 110, (2014) Prostate cancer is associated with a poor survival rate. The ability of cancer cells to evade apoptosis and exhibit limitless replication potential allows for progression of cancer from a benign to a metastatic phenotype. The aim of this study was to investig... |