1-(2-嘧啶基)哌嗪
1-(2-嘧啶基)哌嗪结构式
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常用名 | 1-(2-嘧啶基)哌嗪 | 英文名 | 1-(2-PYRIMIDINYL) PIPERAZINE |
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| CAS号 | 20980-22-7 | 分子量 | 164.208 | |
| 密度 | 1.1±0.1 g/cm3 | 沸点 | 328.0±52.0 °C at 760 mmHg | |
| 分子式 | C8H12N4 | 熔点 | 32-34°C | |
| MSDS | 中文版 美版 | 闪点 | 152.1±30.7 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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The significant inhibition on CYP3A caused by radix Aconiti single herb is not observed in the Wutou decoction: The necessity of combination therapy of radix Aconiti.
J. Ethnopharmacol. 170 , 251-4, (2015) Wutou (WT, Radix Aconiti), the mother root of Aconitum carmichaelii Debx., is a famous Chinese herb against rheumatoid arthritis. In Chinese clinics, PWT is often prepared as a decoction in combination with other herbs, such as Wutou decoction (WTD). The pres... |
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The exposure of highly toxic aconitine does not significantly impact the activity and expression of cytochrome P450 3A in rats determined by a novel ultra performance liquid chromatography-tandem mass spectrometric method of a specific probe buspirone.
Food Chem. Toxicol. 51 , 396-403, (2013) Aconitum species are widely used to treat rheumatism, cardiovascular diseases, and tumors in China and other Asian countries. The herbs are always used with drugs such as paclitaxel. Aconitine (AC) is one of the main bioactive/high-toxic alkaloids of Aconitum... |
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Intravenous buspirone for the prevention of postoperative nausea and vomiting.
Eur. J. Clin. Pharmacol. 68(11) , 1465-72, (2012) Buspirone, a partial 5HT(1A) agonist and D₂ and D₃ antagonist, has shown promising antiemetic efficacy when given parenterally in animal models, but its efficacy for the prevention of postoperative nausea and vomiting (PONV) is unknown.To study the efficacy a... |
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A novel p38 alpha MAPK inhibitor suppresses brain proinflammatory cytokine up-regulation and attenuates synaptic dysfunction and behavioral deficits in an Alzheimer's disease mouse model.
J. Neuroinflammation 4(1) , 21, (2007) An accumulating body of evidence is consistent with the hypothesis that excessive or prolonged increases in proinflammatory cytokine production by activated glia is a contributor to the progression of pathophysiology that is causally linked to synaptic dysfun... |
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Synthesis and evaluation of ligands for D2-like receptors: the role of common pharmacophoric groups.
Bioorg. Med. Chem. 17(4) , 1716-23, (2009) Arylcycloalkylamines, such as phenyl piperidines and piperazines and their arylalkyl substituents, constitute pharmacophoric groups exemplified in several antipsychotic agents. A review of previous reports indicates that arylalkyl substituents can improve the... |
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Oral buspirone causes a shift in the dose-response curve between the elevated-plus maze and Vogel conflict tests in Long-Evans rats: relation of brain levels of buspirone and 1-PP to anxiolytic action.
Methods Find. Exp. Clin. Pharmacol. 27(4) , 245-55, (2005) Most studies concerning the effects of oral buspirone in the rat elevated plus-maze (EPM) test, spontaneous motor activity (SMA) test, and Vogel conflict (VC) test have used Sprague-Dawley or Wistar rats. Although it has been documented that the behavior of L... |
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Chronobiotic effects of gepirone, a potential antidepressant with 5HT1A receptor partial agonist properties.
Behav. Pharmacol. 10(2) , 119-30, (1999) Abnormal timing in the circadian system is reported in endogenous depression. Gepirone, a 5HT1A receptor partial agonist, has anxiolytic and antidepressant properties. We determined whether gepirone was able to modify the functioning of the circadian system. ... |
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Simultaneous quantitation of buspirone and its major metabolite 1-(2-pyrimidinyl)piperazine in human plasma by high-performance liquid chromatography with coulometric detection.
J. Pharm. Biomed. Anal. 14(3) , 347-51, (1996) Buspirone is a member of the azapirone group of anxiolytic drugs and has one major metabolite, 1-(2-pyrimidinyl)piperazine (1-PP). The analyte, its metabolite and the internal standard were extracted from plasma utilizing solid-phase extraction columns. Chrom... |
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Evaluation of the alpha 2-adrenoceptor blocking properties of buspirone and ipsapirone in healthy subjects. Relationship with the plasma concentration of the common metabolite 1-(2-pyrimidinyl)-piperazine.
Br. J. Clin. Pharmacol. 39(3) , 243-9, (1995) 1. Because the 5-HT1A agonist anxiolytic azapirones have a common alpha 2-adrenoceptor antagonist metabolite, 1-(2-pyrimidinyl)-piperazine (1PP), we measured central and peripheral alpha 2-adrenoceptor dependent responses before and after intravenous administ... |
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The influence of buspirone, and its metabolite 1-PP, on the activity of paroxetine in the mouse light/dark paradigm and four plates test.
Pharmacol. Biochem. Behav. 67(1) , 45-53, (2000) Although numerous animal procedures have been employed in the study of antidepressants (ADs) in anxiety, the results following acute administration remain highly variable. The present study investigated the effect of the SSRI paroxetine (4, 8, and 16 mg/kg, I... |