1-(2-吡啶基)哌嗪
1-(2-吡啶基)哌嗪结构式
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常用名 | 1-(2-吡啶基)哌嗪 | 英文名 | 1-(2-Pyridinyl)piperazine |
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| CAS号 | 34803-66-2 | 分子量 | 163.22 | |
| 密度 | 1.1±0.1 g/cm3 | 沸点 | 314.4±22.0 °C at 760 mmHg | |
| 分子式 | C9H13N3 | 熔点 | 92-94 | |
| MSDS | 中文版 美版 | 闪点 | 143.9±22.3 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Pharmacological evidence for the involvement of 1-(2-pyridinyl)-piperazine (1-PmP) in the interaction of buspirone or gepirone with noradrenergic systems.
Eur. J. Pharmacol. 134(1) , 113-6, (1987) We investigated in mice the effects of one of the principal metabolites of buspirone and gepirone, 1-(2-pyridinyl)-piperazine (1-PmP), on hypothermia and reduced locomotion induced by clonidine (0.25 and 0.06 mg/kg, respectively), tests related to brain alpha... |
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6-Hydroxybuspirone is a major active metabolite of buspirone: assessment of pharmacokinetics and 5-hydroxytryptamine1A receptor occupancy in rats.
Drug Metab. Dispos. 35(8) , 1387-92, (2007) The pharmacokinetics and in vivo potency of 6-hydroxybuspirone (6-OH-buspirone), a major metabolite of buspirone, were investigated. The plasma clearance (47.3 +/- 3.5 ml/min/kg), volume of distribution (2.6 +/- 0.3 l/kg), and half-life (1.2 +/- 0.2 h) of 6-O... |
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New lithocholic and chenodeoxycholic piperazinylcarboxamides with antiproliferative and pro-apoptotic effects on human cancer cell lines.
Bioorg. Med. Chem. 16 , 8737-44, (2008) Six new synthetic bile acid derivatives were synthesized and tested in vitro against various human cancer cells (glioblastoma multiforme (GBM), multiple myeloma (KMS-11), and colonic carcinoma (HCT-116) cell lines. The best activity was obtained with compound... |
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Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part II. Identification of the 1,3,8-triazaspiro[4,5]decan-4-one privileged structure that engenders PLD2 selectivity.
Bioorg. Med. Chem. Lett. 19 , 2240-3, (2009) This Letter describes the synthesis and structure-activity relationships (SAR) of isoform-selective PLD inhibitors. By virtue of the installation of a 1,3,8-triazaspiro[4,5]decan-4-one privileged structure, PLD inhibitors with nanomolar potency and an unprece... |
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Determination of trace atmospheric isocyanate concentrations by reversed-phase high-performance liquid chromatography using 1-(2-pyridyl) piperazine reagent. Goldberg PA, et al.
J. Chromatogr. A. 212(1) , 93-104, (1981)
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Determination of atmospheric isocyanate concentrations by high-performance thin-layer chromatography using 1-(2-pyridyl) piperazine reagent. Ellwood PA, et al.
Analyst 106(1258) , 85-93, (1981)
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Absorption and fluorescence of 1-(2-pyridyl)-piperazine and four diisocyanate derivatives in solution. Salthammer T, et al.
J. Photochem. Photobiol. A: Chem. 107(1) , 159-64, (1997)
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Determination of trace atmospheric isocyanate concentrations by reversed-phase high-performance liquid chromatography using 1-(2-pyridyl) piperazine reagent.
J. Chromatogr. A. 212(1) , 93-104, (1981)
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