莫诺苯宗
莫诺苯宗结构式
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常用名 | 莫诺苯宗 | 英文名 | 4-Benzyloxyphenol |
|---|---|---|---|---|
| CAS号 | 103-16-2 | 分子量 | 200.233 | |
| 密度 | 1.2±0.1 g/cm3 | 沸点 | 359.1±17.0 °C at 760 mmHg | |
| 分子式 | C13H12O2 | 熔点 | 119-120 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 213.4±5.9 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
J. Sci. Ind. Res. 65(10) , 808, (2006) Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI types (hepatotoxic side effects) seen in the clinic can be tra... |
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Impact of induced fit on ligand binding to the androgen receptor: a multidimensional QSAR study to predict endocrine-disrupting effects of environmental chemicals.
J. Med. Chem. 48 , 5666-74, (2005) We investigated the influence of induced fit of the androgen receptor binding pocket on free energies of ligand binding. On the basis of a novel alignment procedure using flexible docking, molecular dynamics simulations, and linear-interaction energy analysis... |
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Targeting melanocyte and melanoma stem cells by 8-hydroxy-2-dipropylaminotetralin.
Arch. Biochem. Biophys. 563 , 71-8, (2014) Monobenzyl ether of hydroquinone (MBEH) is cytotoxic towards melanocytes. Its treatment efficacy is limited by an inability to eradicate stem cells. By contrast, 8-hydroxy-N,N-dipropyl-2-aminotetralin (8-DPAT) affects melanocyte stem cell survival. MBEH and 8... |
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Vitiligo-inducing phenols activate the unfolded protein response in melanocytes resulting in upregulation of IL6 and IL8.
J. Invest. Dermatol. 132(11) , 2601-9, (2012) Vitiligo is characterized by depigmented skin patches caused by loss of epidermal melanocytes. Oxidative stress may have a role in vitiligo onset, while autoimmunity contributes to disease progression. In this study, we sought to identify mechanisms that link... |
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Monobenzyl ether of hydroquinone and 4-tertiary butyl phenol activate markedly different physiological responses in melanocytes: relevance to skin depigmentation.
J. Invest. Dermatol. 130(1) , 211-20, (2010) Monobenzyl ether of hydroquinone (MBEH) is a Food and Drug Administration approved drug used for depigmentation therapy of advanced vitiligo. Here, the working mechanism of MBEH is explored in comparison to 4-tertiary butyl phenol (4-TBP), a known causative a... |
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The therapeutic effects of EGCG on vitiligo.
Fitoterapia 99 , 243-51, (2014) Epigallocatechin-3-gallate (EGCG) is one of the main chemical constituents of green tea, which has been used as an important traditional Chinese medicine. Green tea has anti-inflammatory, anti-oxidant, and immunomodulatory properties. However, the effects of ... |
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Influence of depigmenting chemical agents on hair and skin color in yellow (pheomelanic) and black (eumelanic) mice.
Pigment Cell Res. 3(2) , 71-9, (1990) Topical applications of monobenzylether of hydroquinone (MBEH) or intraperitoneal injections of phenol induced graying of hair in eumelanic mice but had little effect on hair color in pheomelanic mice. Amcinonide, an anti-inflammatory agent, elicited whitenin... |
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Dyschromatosis.
Semin. Cutan. Med. Surg. 16(1) , 81-5, (1997) The dyschromatoses are a group of disorders characterized by the presence of both hyperpigmented and hypopigmented macules, many of which are small in size and irregular in shape. There are two major forms-dyschromatosis symmetrica hereditaria (DSH) and dysch... |
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Depigmentation therapies for normal skin in vitiligo universalis.
J. Eur. Acad. Dermatol. Venereol. 25(7) , 749-57, (2011) If vitiligo involves most of the body, it might be easier to depigment the normal remaining skin rather than to attempt repigmentation. We reviewed the literature to date regarding available therapies for depigmenting the normal skin in vitiligo universalis. ... |
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Contact hypersensitivity to monobenzyl ether of hydroquinone used to treat vitiligo.
Contact Dermatitis 39(3) , 132-3, (1998)
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