乙酰肼
乙酰肼结构式
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常用名 | 乙酰肼 | 英文名 | Acethydrazide |
|---|---|---|---|---|
| CAS号 | 1068-57-1 | 分子量 | 74.082 | |
| 密度 | 1.0±0.1 g/cm3 | 沸点 | 246.0±9.0 °C at 760 mmHg | |
| 分子式 | C2H6N2O | 熔点 | 58-68 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 102.6±18.7 °C | |
| 符号 |
GHS06, GHS08 |
信号词 | Danger |
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Stable isotopic labeling-based quantitative targeted glycomics (i-QTaG).
Biotechnol. Prog. 31 , 840-8, (2015) Mass spectrometry (MS) analysis combined with stable isotopic labeling is a promising method for the relative quantification of aberrant glycosylation in diseases and disorders. We developed a stable isotopic labeling-based quantitative targeted glycomics (i-... |
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Development and characterization of Haemophilus influenzae type b conjugate vaccine prepared using different polysaccharide chain lengths.
Vaccine 33 , 2646-54, (2015) Capsular polysaccharide conjugates of Haemophilus influenzae type b (Hib) are important components of several mono- or multi-valent childhood vaccines. However, their access to the most needy people is limited due to their high cost. As a step towards develop... |
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Quantitative glycome analysis of N-glycan patterns in bladder cancer vs normal bladder cells using an integrated strategy.
J. Proteome Res. 14(2) , 639-53, (2015) Diagnosis of bladder cancer, one of the most common types of human cancer, at an early (nonmuscle-invasive) stage is the best way to reduce the mortality rate. Tumor malignancy in general is closely associated with alterations of glycan expression. Glycosylat... |
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Human PXR modulates hepatotoxicity associated with rifampicin and isoniazid co-therapy.
Nat. Med. 19(4) , 418-20, (2013) Co-therapy with rifampicin (RIF) and isoniazid (INH) used to treat tuberculosis in humans frequently causes liver injury. Here, using a pregnane X receptor (PXR)-humanized mouse model, we found that co-treatment with RIF and INH causes accumulation of the end... |
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Pharmacokinetics of the toxic hydrazino metabolites formed from isoniazid in humans.
J. Pharmacol. Exp. Ther. 235(3) , 566-70, (1985) The plasma concentrations of isoniazid and its hydrazino metabolites, acetylisoniazid, acetylhydrazine and diacetylhydrazine, were measured by gas chromatography-mass spectrometry in 12 healthy subjects after the ingestion of 300 mg of isoniazid. The area und... |
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Determination of hydrazine in biofluids by capillary gas chromatography with nitrogen-sensitive or mass spectrometric detection.
J. Chromatogr. A. 573(2) , 227-34, (1992) Plasma and liver levels of hydrazine were determined at 10, 30, 90 and 270 min in rats given 0.09, 0.27, 0.84 and 2.53 mmol of hydrazine per kg body weight orally by capillary gas chromatography-mass spectrometry of its pentafluorobenzaldehyde adduct (DFBA, m... |
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Hepatic gene expression and lipid homeostasis in C57BL/6 mice exposed to hydrazine or acetylhydrazine.
Toxicol. Sci. 82(1) , 318-32, (2004) Hydrazine (HD) and acetylhydrazine (AcHD) are metabolites of the antituberculosis drug isoniazid (INH) that have been implicated in INH-induced liver damage. The hepatotoxicity of AcHD and HD were compared in adult male C57Bl/6J mice by evaluating hepatic his... |
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Identification of novel hydrazine metabolites by 15N-NMR.
Biochem. Pharmacol. 41(9) , 1319-24, (1991) 15N-NMR has been used to study the metabolism of hydrazine in rats in vivo. Single doses of [15N2]hydrazine (2.0 mmol/kg: 98.6% g atom) were administered to rats and urine collected for 24 hr over ice. A number of metabolites were detected by 15N-NMR analysis... |
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Activation of hydrazine derivatives to free radicals in the perfused rat liver: a spin-trapping study.
Biochim. Biophys. Acta 924(2) , 261-9, (1987) Spin-trapping techniques and electron spin resonance spectroscopy have been used to study bioactivations of hydrazine and its derivatives by isolated perfused rat livers. Using phenylbutylnitrone (PBN) as the stable spin trap, it was found that the liver perf... |
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Reaction of pregnenolone with cyanoacetylhydrazine: novel synthesis of hydrazide-hydrazone, pyrazole, pyridine, thiazole, thiophene derivatives and their cytotoxicity evaluations.
Steroids 77(14) , 1551-9, (2012) Pregnenolone (1) was used as a template to develop new anticancer compounds. Ring D modification of 1 through its reaction with cyanoacetylhydrazine (2) gave the hydrazide-hydrazone derivative 3. The latter compound underwent heterocyclization reactions to gi... |