消旋卡多曲
消旋卡多曲结构式
|
常用名 | 消旋卡多曲 | 英文名 | Racecadotril |
|---|---|---|---|---|
| CAS号 | 81110-73-8 | 分子量 | 385.477 | |
| 密度 | 1.2±0.1 g/cm3 | 沸点 | 574.5±50.0 °C at 760 mmHg | |
| 分子式 | C21H23NO4S | 熔点 | 89ºC | |
| MSDS | 中文版 美版 | 闪点 | 301.2±30.1 °C | |
| 符号 |
GHS07, GHS09 |
信号词 | Warning |
|
A comparative study of racecadotril and single dose octreotide as an anti-secretory agent in acute infective diarrhoea.
J. Assoc. Physicians India 60 , 12-5, (2012) To assess the efficacy of single dose of octreotide and compare it with another antisecretory agent racecadotril in the management of acute infective diarrhea.A randomized control study was done in the Department of Medicine and Infectious Disease Hospital (D... |
|
|
Racecadotril versus loperamide: antidiarrheal research revisited.
Dig. Dis. Sci. 48(2) , 239-50, (2003) Racecadotril is an enkephalinase inhibitor, presented as a purely antisecretory agent with advantages over the opiate-receptor agonist loperamide in the treatment of diarrhea. A critical review of the literature and the models used was performed. Although pre... |
|
|
Quantitative analysis of racecadotril metabolite in human plasma using a liquid chromatography/tandem mass spectrometry.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 852(1-2) , 101-7, (2007) Orally administered racecadotril is rapidly hydrolyzed to the more potent enkephalinase inhibitor thiorphan in vivo. A sensitive and specific liquid chromatography/tandem mass spectrometry method was developed and validated to quantify thiorphan in human plas... |
|
|
Colon in acute intestinal infection.
J. Pediatr. Gastroenterol. Nutr. 48 Suppl 2 , S58-62, (2009) The colon is actively implicated in intestinal infections not only as a target of enteric pathogens and their products but also as a target organ for treatment. In the presence of diarrhea, both of osmotic and secretory nature, the colon reacts with homeostat... |
|
|
A rapid and validated HPLC method to quantify racecadotril metabolite, thiorphan, in human plasma using solid-phase extraction.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 861(1) , 130-5, (2008) A HPLC method with UV detection was developed and validated for the determination of thiorphan in human plasma. Nevirapine was used as the internal standard. Separation was performed by a Waters sunfire C18 reversed-phase column maintained at 35 degrees C. Th... |
|
|
Hypersensitivity to racecadotril: a case report.
Eur. J. Pediatr. 165(6) , 418-9, (2006)
|
|
|
Increase of plasma insulin by racecadotril, an inhibitor of enkephalinase, in Wistar rats.
Horm. Metab. Res. 42(4) , 261-7, (2010) Racecadotril is known as an inhibitor of enkephalinase. Increase of plasma insulin by racecadotril has been observed in rats while the mechanism of the action remains obscure. In the present study, intravenous injection of male Wistar rats with racecadotril s... |
|
|
Stability-indicating methods for the determination of racecadotril in the presence of its degradation products.
Biosci. Trends 3(6) , 247-52, (2009) Three stability-indicating methods were developed for the determination of racecadotril (RCT) in the presence of its alkaline degradation products. The first was an HPLC method in which efficient chromatographic separation was achieved on a C18 analytical col... |
|
|
Structural studies of racecadotril and its process impurities by NMR and mass spectroscopy.
Pharmazie 61(12) , 994-8, (2006) Three unknown impurities in racecadotril bulk drug at levels below 0.5% were detected by simple reverse phase isocratic high performance liquid chromatography (HPLC). Structures for these impurities were proposed by molecular ion information and their fragmen... |
|
|
[Prevention and treatment of acute diarrhea in infants].
Arch. Pediatr. 14(11) , 1375-8, (2007) The prognosis of acute diarrhoea in infants is most often satisfactory in industrialized countries. However, it has been estimated that 10 to 15 children die every year in France from acute dehydration due to acute diarrhoea. In spite of an increasing use ove... |