五味子醇甲
五味子醇甲结构式
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常用名 | 五味子醇甲 | 英文名 | Schisandrol A |
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| CAS号 | 7432-28-2 | 分子量 | 432.507 | |
| 密度 | 1.1±0.1 g/cm3 | 沸点 | 576.7±50.0 °C at 760 mmHg | |
| 分子式 | C24H32O7 | 熔点 | 128-129ºC | |
| MSDS | 中文版 美版 | 闪点 | 302.6±30.1 °C | |
| 符号 |
GHS07, GHS09 |
信号词 | Warning |
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Effects of acupuncture at ST36 on pharmacokinetics of Schisandra lignans in rats.
Acupunct. Med. 33 , 223-9, (2015) To investigate the influence of acupuncture at ST36 on the pharmacokinetics of Schisandra lignans including schisandrin, deoxyschisandrin and schisandrin B after intragastric administration of Schisandra chinensis (SC) in rats.Twelve male Sprague-Dawley rats ... |
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Comparative pharmacokinetics and tissue distribution profiles of lignan components in normal and hepatic fibrosis rats after oral administration of Fuzheng Huayu recipe.
J. Ethnopharmacol. 166 , 305-12, (2015) Fuzheng Huayu recipe (FZHY) is formulated on the basis of Chinese medicine theory in treating liver fibrosis.To illuminate the influence of the pathological state of liver fibrosis on the pharmacokinetics and tissue distribution profiles of lignan components ... |
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The Lignan-containing Extract of Schisandra chinensis Berries Inhibits the Growth of Chlamydia pneumonia.
Nat. Prod. Commun. 10 , 1001-4, (2015) The purpose of this study was to investigate the effect and selectivity of an extract of Schisandra chinensis berries against Chlamydia pneumoniae and C. trachomatis. Among the ethnopharmacological uses of the extract from Schisandrae fructus are cough and pn... |
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Quantitative analysis of major dibenzocyclooctane lignans in Schisandrae fructus by online TLC-DART-MS.
Phytochem. Anal. 22(3) , 258-62, (2011) Direct analysis in real time (DART) ion source is a powerful ionising technique for the quick and easy detection of various organic molecules without any sample preparation steps, but the lack of quantitation capacity limits its extensive use in the field of ... |
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Pharmacokinetic study of schisandrin, schisandrol B, schisantherin A, deoxyschisandrin, and schisandrin B in rat plasma after oral administration of Shengmaisan formula by UPLC-MS.
J. Sep. Sci. 36(3) , 485-91, (2013) Shengmaisan (SMS) is a traditional Chinese medicine prescription widely used for the treatment of cardiovascular diseases in Asia. Its lignans are major components responsible for therapeutic action. A rapid and specific UPLC-Q-TOF/MS has been developed and v... |
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Schizandrin protects primary rat cortical cell cultures from glutamate-induced apoptosis by inhibiting activation of the MAPK family and the mitochondria dependent pathway.
Molecules 18(1) , 354-72, (2012) Glutamate-induced excitotoxicity has been implicated in a variety of neuronal degenerative disorders. In the present study, we investigated the possible neuroprotective effects of schizandrin against apoptosis of primary cultured rat cortical cells induced by... |
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Preparation of high purity biphenyl cyclooctene lignans from Schisandra extract by ion exchange resin catalytic transformation combined with macroporous resin separation.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 879(30) , 3444-51, (2011) In this study, ester-bond biphenyl cyclooctene lignans were efficiently hydrolytically degraded into free biphenyl cyclooctene lignans by ion exchange resin transformation and simultaneous removal of impurities by macroporous resin. The OH-type strongly basic... |
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Relaxant effects of Schisandra chinensis and its major lignans on agonists-induced contraction in guinea pig ileum.
Phytomedicine 18(13) , 1153-60, (2011) In this study, the herbal extracts of Schisandra chinensis were demonstrated to inhibit the contractions induced by acetylcholine (ACh) and serotonin (5-HT) in guinea pig ileum, and the 95% ethanol extract was more effective than the aqueous extract. Analysis... |
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Inhibitory effect of schisandrin on spontaneous contraction of isolated rat colon.
Phytomedicine 18(11) , 998-1005, (2011) This study examined the effect of schisandrin, one of the major lignans isolated from Schisandra chinensis, on spontaneous contraction in rat colon and its possible mechanisms. Schisandrin produced a concentration-dependent inhibition (EC₅₀=1.66 μM) on the co... |
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Schizandrin, an antioxidant lignan from Schisandra chinensis, ameliorates Aβ1-42-induced memory impairment in mice.
Oxid. Med. Cell. Longev. 2012 , 721721, (2012) In the present study, we examined the effect of schisandrin (SCH) of Schisandra chinensis on the amyloid-beta(1-42)- (Aβ(1-42)-) induced memory impairment in mice and elucidated the possible antioxidative mechanism. Mice were intracerebroventricular (i.c.v.) ... |