马兜铃酸A
马兜铃酸A结构式
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常用名 | 马兜铃酸A | 英文名 | Aristolochic acid A |
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| CAS号 | 313-67-7 | 分子量 | 341.27 | |
| 密度 | 1.6±0.1 g/cm3 | 沸点 | 615.5±55.0 °C at 760 mmHg | |
| 分子式 | C17H11NO7 | 熔点 | 260 °C | |
| MSDS | 中文版 美版 | 闪点 | 326.0±31.5 °C | |
| 符号 |
GHS06 |
信号词 | Danger |
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Bardoxolone methyl (BARD) ameliorates aristolochic acid (AA)-induced acute kidney injury through Nrf2 pathway.
Toxicology 318 , 22-31, (2014) Bardoxolone methyl (BARD) is an antioxidant modulator that acts through induction of the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway. This study aimed to investigate the role of BARD in protecting kidneys from aristolochic acid (AA)-i... |
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Baicalin Protects Mice from Aristolochic Acid I-Induced Kidney Injury by Induction of CYP1A through the Aromatic Hydrocarbon Receptor.
Int. J. Mol. Sci. 16 , 16454-68, (2015) Exposure to aristolochic acid I (AAI) can lead to aristolochic acid nephropathy (AAN), Balkan endemic nephropathy (BEN) and urothelial cancer. The induction of hepatic CYP1A, especially CYP1A2, was considered to detoxify AAI so as to reduce its nephrotoxicity... |
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Association of blood lead and mercury with estimated GFR in herbalists after the ban of herbs containing aristolochic acids in Taiwan.
Occup. Environ. Med. 70(8) , 545-51, (2013) This study was undertaken to explore the association of estimated glomerular filtration rate (GFR) with exposure to aristolochic acids (ALAs) and nephrotoxic metals in herbalists after the ban of herbs containing ALAs in Taiwan.This cross-sectional study recr... |
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Harpalycin 2 inhibits the enzymatic and platelet aggregation activities of PrTX-III, a D49 phospholipase A2 from Bothrops pirajai venom.
BMC Complement Altern. Med. 12 , 139, (2012) Harpalycin 2 (HP-2) is an isoflavone isolated from the leaves of Harpalyce brasiliana Benth., a snakeroot found in northeast region of Brazil and used in folk medicine to treat snakebite. Its leaves are said to be anti-inflammatory. Secretory phospholipases A... |
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Increased expression of p21WAF1/CIP1 in kidney proximal tubules mediates fibrosis.
Am. J. Physiol. Renal Physiol. 308(2) , F122-30, (2015) Tissue fibrosis is a major cause of death in developed countries. It commonly occurs after either acute or chronic injury and affects diverse organs, including the heart, liver, lung, and kidney. Using the renal ablation model of chronic kidney disease, we pr... |
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Exceptionally long-term persistence of DNA adducts formed by carcinogenic aristolochic acid I in renal tissue from patients with aristolochic acid nephropathy.
Int. J. Cancer 135(2) , 502-7, (2014) Aristolochic acid (AA) causes aristolochic acid nephropathy (AAN), first described in women in Belgium accidently prescribed Aristolochia fangchi in a slimming treatment, and also Balkan endemic nephropathy (BEN), through probable dietary contamination with A... |
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A Balkan riddle's serendipitous solution.
Science 344(6180) , 146, (2014)
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[Advances in studies on pharmacokinetics of aristolochic acid I].
Zhongguo Zhong Yao Za Zhi 31(19) , 1573-5, (2006) Aristolochic acid I (AA-I) was absorbed and distributed quickly in vivo, the plasma concentration-time curve were fit with the open two-compartment model and one-compartment model, respectively. The elimination of AA-I has relationship with the dosage, the lo... |
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Local uses of Aristolochia species and content of nephrotoxic aristolochic acid 1 and 2--a global assessment based on bibliographic sources.
J. Ethnopharmacol. 125(1) , 108-44, (2009) More than 100 cases of nephropathy over the last 10 years caused by the systemic and longer term application of Chinese snakeroot (Aristolochia fangchi) highlighted the risk of using preparations which contain aristolochic acids. On the other hand anecdotal e... |
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Nerve growth factor stimulates cardiac regeneration via cardiomyocyte proliferation in experimental heart failure.
PLoS ONE 7(12) , e53210, (2012) Although the adult heart likely retains some regenerative capacity, heart failure (HF) typically remains a progressive disorder. We hypothesise that alterations in the local environment contribute to the failure of regeneration in HF. Previously we showed tha... |