(±)-PPHT盐酸盐
(±)-PPHT盐酸盐结构式
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常用名 | (±)-PPHT盐酸盐 | 英文名 | (+/-)-PPHT HYDROCHLORIDE (N-0434) POTENT D2 DOPAMINE RE |
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| CAS号 | 71787-90-1 | 分子量 | 345.90600 | |
| 密度 | N/A | 沸点 | 468ºC at 760 mmHg | |
| 分子式 | C21H28ClNO | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | 228.6ºC |
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Differential effects of dopamine D1 and D2 receptor agonists on schedule-controlled behavior of squirrel monkeys.
J. Pharmacol. Exp. Ther. 273 , 40, (1995) The effects of dopamine agonists differing in affinity and selectivity at D1 and D2 types of dopamine receptors were compared in squirrel monkeys responding under two different schedules of reinforcement: a fixed-interval (FI) schedule of stimulus-shock termi... |
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Multiple fluorescent ligands for dopamine receptors. I. Pharmacological characterization and receptor selectivity.
Brain Res. 547(2) , 199-207, (1991) We report the synthesis and pharmacological characterization of novel fluorescently labeled ligands with high affinity and specificity for D1 and D2 dopamine receptors. D1-selective antagonist probes have been synthesized using (R,S)-5-(4'-aminophenyl)-8-chlo... |
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Relations between the extracellular concentrations of choline and acetylcholine in rat striatum.
J. Neurochem. 69(3) , 1246-51, (1997) Changes in extracellular levels of acetylcholine (ACh) and choline (Ch) in the striatum of rats were examined by in vivo microdialysis after intraperitoneal injections of drugs. A dopamine D2 antagonist, sulpiride (20 mg/kg), and a muscarinic antagonist, atro... |
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Biphasic effects of dopamine agonist N-0434 on locomotor behaviors in rats.
Pharmacol. Biochem. Behav. 44(4) , 865-8, (1993) The effects of a dopamine agonist, (+/-)-2-(N-penylethyl-N-propyl)amino-5- hydroxytetralin (N-0434) (SC doses of 0.00, 0.01, 0.1, and 1.0 mg/kg) were tested in rats for 120 min in an activity monitor. The durations in seconds of horizontal locomotor time, rea... |
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Adenylate cyclase from sea urchin eggs is positively and negatively regulated by D-1 and D-2 dopamine receptors.
Exp. Cell Res. 203(2) , 491-4, (1992) The adenylate cyclase present in membranes prepared from sea urchin eggs is sensitive to dopamine stimulation. The receptor sites coupled to sea urchin adenylate cyclase were characterized by means of specific agonists and antagonists. The D-1 dopamine agonis... |
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Transient loss of dopamine autoreceptor control in the presence of highly potent dopamine agonists.
Life Sci. 59(21) , PL317-24, (1996) The concentrations of endogenous ligands generally remain in a bounded range around a basal level, a manifestation of control. The dopaminergic system is an excellent example of a control system in which a negative feedback signal is associated with receptor ... |
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Binding characteristics of high-affinity dopamine D2/D3 receptor agonists, 11C-PPHT and 11C-ZYY-339 in rodents and imaging in non-human primates by PET.
Synapse 54(2) , 83-91, (2004) We have evaluated the in vitro autoradiographic binding characteristics and in vivo brain distribution of two high-affinity dopamine D2/D3 receptor agonists, (+/-)-2-(N-phenethyl-N-1'-11C-propyl)amino-5-hydroxytetralin (11C-PPHT) and (+/-)-2-(N-cyclohexylethy... |
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Existence of postsynaptic dopamine D2 receptor as an enhancer of contractile response in vas deferens.
Eur. J. Pharmacol. 344(2-3) , 223-9, (1998) Effects of dopamine and (+/-)-2-(N-phenylethyl-N-propyl)amino-5-hydroxy-tetralin hydrochloride (N-0434), a dopamine D2 receptor agonist, in the presence of prazosin on the ATP- and acetylcholine-induced contraction were investigated in the guinea-pig vas defe... |
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Suppression of cholinergic activity via the dopamine D2 receptor in the rat striatum.
Neurochem. Int. 30(2) , 191-7, (1997) The effect of dopamine (DA) D2 receptor on extracellular choline (Ch) and acetylcholine (ACh) levels in rat caudate-putamen (striatum) was investigated by means of microdialysis. The systemic, intraperitoneal (i.p.), injection of (+/-)-2-(N-phenylethyl-N-prop... |
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A new approach to finding specific dopamine D4 receptor agonists.
Eur. J. Pharmacol. 516(2) , 145-50, (2005) This paper describes a new approach to finding specific dopamine D4 receptor agonists based on pharmacological analysis of the contractile response to ATP in guinea pig vas deferens. A partial cDNA of the dopamine D4 receptor of the vas deferens was identifie... |