三甲沙林
三甲沙林结构式
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常用名 | 三甲沙林 | 英文名 | Trioxsalen |
|---|---|---|---|---|
| CAS号 | 3902-71-4 | 分子量 | 228.243 | |
| 密度 | 1.2±0.1 g/cm3 | 沸点 | 389.0±30.0 °C at 760 mmHg | |
| 分子式 | C14H12O3 | 熔点 | 229-231ºC(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 189.1±24.6 °C | |
| 符号 |
GHS05, GHS08 |
信号词 | Danger |
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Mitotic cohesin subunit Mcd1 regulates the progression of meiotic recombination in budding yeast.
J. Microbiol. Biotechnol. 25 , 598-605, (2015) The cohesin complex holds sister chromatids together and prevents premature chromosome segregation until the onset of anaphase. Mcd1 (also known as Scc1), the α-kleisin subunit of cohesin, is a key regulatory subunit of the mitotic cohesin complex and is requ... |
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Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells.
J. Cell Biol. 208(5) , 563-79, (2015) Replication fork reversal protects forks from breakage after poisoning of Topoisomerase 1. We here investigated fork progression and chromosomal breakage in human cells in response to a panel of sublethal genotoxic treatments, using other topoisomerase poison... |
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Psoralen conjugates for visualization of genomic interstrand cross-links localized by laser photoactivation.
Bioconjug. Chem. 18(2) , 431-7, (2007) DNA interstrand cross-links are formed by chemotherapy drugs as well as by products of normal oxidative metabolism. Despite their importance, the pathways of cross-link metabolism are poorly understood. Laser confocal microscopy has become a powerful tool for... |
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Scoring function for DNA–drug docking of anticancer and antiparasitic compounds based on spectral moments of 2D lattice graphs for molecular dynamics trajectories
Eur. J. Med. Chem. 44 , 4461-9, (2009) We introduce here a new class of invariants for MD trajectories based on the spectral moments π k (L) of the Markov matrix associated to lattice network-like (LN) graph representations of Molecular Dynamics (MD) trajectories. The procedure embeds the MD energ... |
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Development of a novel furocoumarin derivative inhibiting NF-κB dependent biological functions: design, synthesis and biological effects.
Eur. J. Med. Chem. 46 , 4870-7, (2011) Nuclear Factor kappaB (NF-κB) plays a very important role in the control of gene expression and is deeply involved in several human pathologies. Accordingly, molecules targeting NF-κB dependent biological functions are considered of great interest. Virtual sc... |
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Functional Validation of Rare Human Genetic Variants Involved in Homologous Recombination Using Saccharomyces cerevisiae.
PLoS ONE 10 , e0124152, (2015) Systems for the repair of DNA double-strand breaks (DSBs) are necessary to maintain genome integrity and normal functionality of cells in all organisms. Homologous recombination (HR) plays an important role in repairing accidental and programmed DSBs in mitot... |
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DNA interstrand crosslinks repair in mammalian cells.
Z. Naturforsch., C, J. Biosci. 63(3-4) , 289-96, (2008) We studied the formation of double strand breaks (DSBs) as intermediates in the repair of DNA interstrand crosslinks (ICLs) by homologous recombination (HR). The plasmid EGFP-N1 was crosslinked with trioxsalen to give one ICL per plasmid on average. HeLa cell... |
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Role of tacrolimus (FK506) 0.1% ointment WW in vitiligo in children and imperatives of combine therapy with Trioxsalen and Silymarin suspension in progressive vitiligo.
J. Eur. Acad. Dermatol. Venereol. 23(10) , 1218-9, (2009)
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In vivo footprint of a picornavirus internal ribosome entry site reveals differences in accessibility to specific RNA structural elements.
J. Gen. Virol. 88(Pt 11) , 3053-62, (2007) Internal ribosome entry site (IRES) elements were described in picornaviruses as an essential region of the viral RNA. Understanding of IRES function requires a detailed knowledge of each step involved in the internal initiation process, from RNA folding and ... |
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Photoallergic contact dermatitis to 8-methoxypsoralen in Ficus carica.
Contact Dermatitis 62(6) , 343-8, (2010) Photocontact dermatitis to Ficus carica is induced by furocoumarins present in sap. These substances are generally considered to cause phototoxic reactions.We conducted a patch test and histopathological study of patients with phytophoto contact dermatitis fr... |