蔷薇霉素
蔷薇霉素结构式
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常用名 | 蔷薇霉素 | 英文名 | rosamicin |
|---|---|---|---|---|
| CAS号 | 35834-26-5 | 分子量 | 581.73800 | |
| 密度 | 1.17g/cm3 | 沸点 | 734.7ºC at 760mmHg | |
| 分子式 | C31H51NO9 | 熔点 | 119-122° | |
| MSDS | 美版 | 闪点 | 398.1ºC | |
| 符号 |
GHS07 |
信号词 | Warning |
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A new Micromonospora-produced macrolide antibiotic, rosamicin.
J. Antibiot. 25 , 641, (1972)
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Function of cytochrome P450 enzymes RosC and RosD in the biosynthesis of rosamicin macrolide antibiotic produced by Micromonospora rosaria.
Antimicrob. Agents Chemother. 57(3) , 1529-31, (2013) The cytochrome P450 enzyme-encoding genes rosC and rosD were cloned from the rosamicin biosynthetic gene cluster of Micromonospora rosaria IFO13697. The functions of RosC and RosD were demonstrated by gene disruption and complementation with M. rosaria and bi... |
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Role of glycosylation and deglycosylation in biosynthesis of and resistance to oleandomycin in the producer organism, Streptomyces antibioticus.
J. Bacteriol. 174(1) , 161-5, (1992) Cell extracts of Streptomyces antibioticus, an oleandomycin producer, can inactivate oleandomycin in the presence of UDP-glucose. The inactivation can be detected through the loss of biological activity or by alteration in the chromatographic mobility of the ... |
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Sample preparation strategy for the simultaneous determination of macrolide antibiotics in animal feedingstuffs by liquid chromatography with electrochemical detection (HPLC-ECD).
J. Pharm. Biomed. Anal. 43(5) , 1628-37, (2007) A novel and suitable clean-up method that allows, for the first time, the simultaneous determination of a rather large number of macrolide antibiotics (erythromycin, rosamicin, spiramycin, tylosin, kitasamycin and josamycin in feedingstuffs by high performanc... |
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Repromicin derivatives with potent antibacterial activity against Pasteurella multocida.
J. Med. Chem. 40(6) , 1041-5, (1997) Reductive amination of repromicin with polyfunctional amines has led to new macrolide antibacterial agents, some of which are highly potent against the Gram-negative pathogen Pasteurella multocida both in vitro and in a mouse infection model. A key element in... |
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Comparative study of coulometric and amperometric detection for the determination of macrolides in human urine using high-performance liquid chromatography.
Anal. Bioanal. Chem 375(8) , 1031-7, (2003) A high-performance liquid chromatography (HPLC) method using chromatographic conditions optimised in a previous work was applied for the separation of three macrolide antibiotics roxithromycin (Rox), oleandomycin (Ole) and rosamicin (Ros) and further determin... |
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Production of rosamicin derivatives in Micromonospora rosaria by introduction of D-mycinose biosynthetic gene with PhiC31-derived integration vector pSET152.
J. Ind. Microbiol. Biotechnol. 36(8) , 1013-21, (2009) Some of the polyketide-derived bioactive compounds contain sugars attached to the aglycone core, and these sugars often impart specific biological activity to the molecule or enhance this activity. Mycinamicin II, a 16-member macrolide antibiotic produced by ... |
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Isolation and characterization of 23-O-mycinosyl-20-dihydro-rosamicin: a new rosamicin analogue derived from engineered Micromonospora rosaria.
J. Antibiot. 63(6) , 325-8, (2010)
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Effect of intercalating dyes on the production of antibiotics by Micromonospora rosaria and Micromonospora purpurea.
Enzyme Microb. Technol. 12(8) , 564-70, (1990) The effect of treatment with various intercalating dyes on the ability to produce antibiotics in Micromonospora rosaria and Micromonospora purpurea was studied. Treatment with acriflavine resulted in a high frequency loss of antibiotic productivity in both sp... |
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New analogues of rosaramicin isolated from a Micromonospora strain. I. Taxonomy, fermentation, isolation and physico-chemical and biological properties.
J. Antibiot. 43(8) , 938-47, (1990) Antibiotics 6108 A1, B, C and D, a new series of analogues of rosaramicin, were found together with rosaramicin, juvenimicin A4 and M-4365 A1 from the cultured broth of strain BA06108 which was assigned to be a new species of Micromonospora. 6108 A1 and C sho... |