诺拉霉素
诺拉霉素结构式
|
常用名 | 诺拉霉素 | 英文名 | Nogalamycin |
|---|---|---|---|---|
| CAS号 | 1404-15-5 | 分子量 | 787.80 | |
| 密度 | 1.49g/cm3 | 沸点 | 899.9ºC at 760mmHg | |
| 分子式 | C39H49NO16 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 498.1ºC | |
| 符号 |
GHS07, GHS08 |
信号词 | Danger |
|
Kinetic characterization of small DNA-binding molecules interacting with a DNA strand on a quartz crystal microbalance.
Anal. Biochem. 492 , 34-42, (2015) Quantitative studies of the binding of various DNA-binding antibiotics with dsDNA are useful for drug design, not only for effective antibiotics, but also for antitumor drugs. We studied the binding kinetics, association and dissociation rate constants, and a... |
|
|
The intercalation of DNA double helices with doxorubicin and nogalamycin.
J. Mol. Graph. Model. 26(1) , 14-9, (2007) A variety of molecules bind to DNA in its major and minor grooves, and some, like the anthraquinoids, are known to form intercalates in which these molecules are inserted directly into the double helix, between the bases. Several researchers have pointed to a... |
|
|
Engineering anthracycline biosynthesis toward angucyclines.
Antimicrob. Agents Chemother. 47(4) , 1291-6, (2003) The biosynthesis pathways of two anthracyclines, nogalamycin and aclacinomycin, were directed toward angucyclines by using an angucycline-specific cyclase, pgaF, isolated from a silent antibiotic biosynthesis gene cluster. Addition of pgaF to a gene cassette ... |
|
|
Expression, purification and crystallization of the cofactor-independent monooxygenase SnoaB from the nogalamycin biosynthetic pathway.
Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 65(Pt 3) , 256-9, (2009) 12-deoxy-nogalonic acid oxygenase (SnoaB) catalyzes the oxygenation of 12-deoxy-nogalonic acid at position 12 to yield nogalonic acid, which is one of the steps in the biosynthesis of the polyketide nogalamycin in Streptomyces nogalater. SnoaB belongs to a fa... |
|
|
Influence of initial charge state on fragmentation patterns for noncovalent drug/DNA duplex complexes.
J. Mass Spectrom. 40(10) , 1362-71, (2005) The charge state-dependent dissociation of various DNA duplexes and drug/duplex complexes has been investigated using collisionally activated dissociation (CAD) in a quadrupole ion trap mass spectrometer (QIT-MS). Several non-self-complementary 14-residue oli... |
|
|
Discovery of a Two-Component Monooxygenase SnoaW/SnoaL2 Involved in Nogalamycin Biosynthesis
Chem. Biol. 19(5) , 638-46, (2012) Nogalamycin is an anthracycline polyketide antibiotic that contains two deoxysugars, at positions C-1 and C-7. Previous biosynthetic studies conducted in vivo affiliated snoaL2 with an unusual C-1 hydroxylation reaction, but in vitro activity was not establis... |
|
|
The biochemical pharmacology of nogalamycin and its derivatives.
Pharmacol. Ther. 51(2) , 239-55, (1991) This review assimilates up-to-date information on the biochemical pharmacology of nogalamycin and selected derivatives that have shown good biological activities and/or received a relatively detailed investigation. The structure and chemical preparation of th... |
|
|
A model study for constructing the DEF-benzoxocin ring system of menogaril and nogalamycin via a reductive Heck cyclization.
Org. Lett. 14(8) , 1962-5, (2012) A novel reductive Heck cyclization approach was developed in order to construct a model DEF-benzoxocin ring system that is present in nogalamycin, menogaril, and related anthracycline antitumor antibiotics.© 2012 American Chemical Society |
|
|
A novel nuclear DNA helicase with high specific activity from Pisum sativum catalytically translocates in the 3'-->5' direction.
Eur. J. Biochem. 270(8) , 1735-45, (2003) A novel ATP-dependent nuclear DNA unwinding enzyme from pea has been purified to apparent homogeneity and characterized. This enzyme is present at extremely low abundance and has the highest specific activity among plant helicases. It is a heterodimer of 54 a... |
|
|
Complexation of anthracycline drugs with DNA in the presence of caffeine.
Eur. Biophys. J. 36(1) , 1-11, (2006) The competitive binding of anthracycline antitumour drugs, [daunomycin (DAU), doxorubicin (DOX) or nogalamycin (NOG)], with caffeine (CAF) to a model DNA oligomer has been investigated by 500 MHz 1H NMR spectroscopy under physiological solution conditions. Th... |