醋酸甲地孕酮
醋酸甲地孕酮结构式
|
常用名 | 醋酸甲地孕酮 | 英文名 | Megestrol acetate |
|---|---|---|---|---|
| CAS号 | 595-33-5 | 分子量 | 384.509 | |
| 密度 | 1.2±0.1 g/cm3 | 沸点 | 507.1±50.0 °C at 760 mmHg | |
| 分子式 | C24H32O4 | 熔点 | 214°C | |
| MSDS | 中文版 美版 | 闪点 | 218.5±30.2 °C | |
| 符号 |
GHS08 |
信号词 | Warning |
|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Chem. Res. Toxicol. 23 , 171-83, (2010) Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental drug discovery projects toward safer medicines. In this st... |
|
|
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
J. Sci. Ind. Res. 65(10) , 808, (2006) Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI types (hepatotoxic side effects) seen in the clinic can be tra... |
|
|
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Bioorg. Med. Chem. 18 , 2225-31, (2010) There are many of pathogen parasite species with different susceptibility profile to antiparasitic drugs. Unfortunately, almost QSAR models predict the biological activity of drugs against only one parasite species. Consequently, predicting the probability wi... |
|
|
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
J. Med. Chem. 51 , 6740-51, (2008) The work provides a new model for the prediction of the MAO-A and -B inhibitor activity by the use of combined complex networks and QSAR methodologies. On the basis of the obtained model, we prepared and assayed 33 coumarin derivatives, and the theoretical pr... |
|
|
Fenretinide: a novel treatment for endometrial cancer.
PLoS ONE 9(10) , e110410, (2014) Resistance to progestin treatment is a major hurdle in the treatment of advanced and reoccurring endometrial cancer. Fenretinide is a synthetic retinoid that has been evaluated in clinical trials as a cancer therapeutic and chemo-preventive agent. Fenretinide... |
|
|
Tolerability and pharmacokinetics of two formulations of megestrol acetate under fed conditions in healthy volunteers.
Clin. Ther. 37(2) , 439-47, (2015) Megestrol acetate oral suspension is an appetite stimulant indicated for cachexia. It is available in a conventional formulation and as a nanocrystal dispersion. The aim of this study was to compare the tolerability and pharmacokinetics of these formulations ... |