2-咪唑烷酮
2-咪唑烷酮结构式
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常用名 | 2-咪唑烷酮 | 英文名 | 2-Imidazolidinone |
|---|---|---|---|---|
| CAS号 | 120-93-4 | 分子量 | 86.092 | |
| 密度 | 1.1±0.1 g/cm3 | 沸点 | 358.7±11.0 °C at 760 mmHg | |
| 分子式 | C3H6N2O | 熔点 | 129-132 °C(lit.) | |
| MSDS | 美版 | 闪点 | 202.5±19.4 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Computational thermochemistry of six ureas, imidazolidin-2-one, N,N'-trimethyleneurea, benzimidazolinone, parabanic acid, barbital (5,5'-diethylbarbituric acid), and 3,4,4'-trichlorocarbanilide, with an extension to related compounds.
J. Phys. Chem. A 114(34) , 9237-45, (2010) A computational study of the structural and thermochemical properties of N-phenyl (open) and N-alkyl (cyclic) ureas, through the use of M05-2X and B3LYP density functional theory calculations has been carried out. The consistency of the literature experimenta... |
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Synthesis of new unsymmetrical 4,5-dihydroxy-2-imidazolidinones. Dynamic NMR spectroscopic study of the prototropic tautomerism in 1-(2-benzimidazolyl)-3-phenyl-4,5-dihydroxy-2-imidazolidinone.
Molecules 11(10) , 768-75, (2006) The acid-catalyzed cyclocondensation in refluxing acetonitrile of aqueous glyoxal with N-heteroaryl-N'-phenylureas 4a-f (heteroaryl = 2-thiazolyl, 2-pyrimidinyl,2-pyrazinyl, 2-pyridinyl, 3-pyridinyl and 2-benzimidazolyl) led to the formation of the correspond... |
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[Preliminary pharmacological evaluation of new imidazolidinone-2, ethylenediamine and imidazoline derivatives].
Acta Pol. Pharm. 41(4) , 495-504, (1984)
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Exploration of a series of 5-arylidene-2-thioxoimidazolidin-4-ones as inhibitors of the cytolytic protein perforin.
J. Med. Chem. 56(23) , 9542-55, (2013) A series of novel 5-arylidene-2-thioxoimidazolidin-4-ones were investigated as inhibitors of the lymphocyte-expressed pore-forming protein perforin. Structure-activity relationships were explored through variation of an isoindolinone or 3,4-dihydroisoquinolin... |
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[Synthesis and structural study of 5-arylidene thiazolidine-2,4-diones and 3-substituted-4-thio-imidazolidine-2-ones].
Ann. Pharm. Fr. 53(5) , 209-14, (1995) The synthesis and the physico-chemical properties of four 3-(4-bromophenacyl)-5-arylidene-thiazolidine-2,4-diones, two 3-(4-bromobenzyl)-5-arylidene-thiazolidine-2,4-diones and seven 3-(4-chlorobenzyl)-5-arylidene-4-thio-imidazolidine-2-ones were described. T... |
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[Pharmacologic studies of new derivatives of imidazoline, 2-imidazolidinone and imidazolidine-2-thione].
Acta Pol. Pharm. 43(2) , 180-8, (1986)
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[Pharmacological studies of the central effects of new ethylguanidine, imidazolidine and imidazolidinone-2 derivatives].
Acta Pol. Pharm. 44(1) , 107-15, (1987)
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[Polyadenylate polymerase in the diagnosis of the early stages of chemical carcinogenesis].
Gig. Tr. Prof. Zabol. (2) , 25-8, (1988)
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Difference in teratogenic potency of ethylenethiourea in rats and mice: relative contribution of embryonic and maternal factors.
Teratology 40(6) , 555-66, (1989) Ethylenethiourea (ETU) is a potent teratogen in the rat but not in the mouse or any other species tested. Embryotoxic and teratogenic effects are produced in mice only after exposure to 10-40 times the teratogenic dose of ETU in rats. This study was undertake... |
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Rational design of novel, potent piperazinone and imidazolidinone BACE1 inhibitors.
Bioorg. Med. Chem. Lett. 18(11) , 3236-41, (2008) Guided by structure-based design, we synthesized two novel series of potent inhibitors of BACE1 and generated extensive SAR around both the prime and non-prime side binding pockets. The key feature of both series is a cyclic amine motif specifically crafted t... |