去乙基阿莫地喹盐酸盐
去乙基阿莫地喹盐酸盐结构式
|
常用名 | 去乙基阿莫地喹盐酸盐 | 英文名 | N-Desethyl amodiaquine dihydrochloride |
|---|---|---|---|---|
| CAS号 | 79049-30-2 | 分子量 | 400.73 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C18H20Cl3N3O | 熔点 | N/A | |
| MSDS | N/A | 闪点 | 9 °C | |
| 符号 |
GHS02, GHS06, GHS08 |
信号词 | Danger |
|
In vitro susceptibility of Plasmodium falciparum to monodesethylamodiaquine, quinine, mefloquine and halofantrine in Abidjan (Côte d'Ivoire).
Afr. Health Sci. 10(2) , 111-6, (2010) Malaria is the primary cause of hospitalization in Côte d'Ivoire. Early treatment is one of the strategies to control this illness. However, the spread of resistance of Plasmodium falciparum to antimalarial drugs can seriously compromise this strategy.The aim... |
|
|
Quantitative assessment of Plasmodium falciparum sexual development reveals potent transmission-blocking activity by methylene blue.
Proc. Natl. Acad. Sci. U. S. A. 108(47) , E1214-23, (2011) Clinical studies and mathematical models predict that, to achieve malaria elimination, combination therapies will need to incorporate drugs that block the transmission of Plasmodium falciparum sexual stage parasites to mosquito vectors. Efforts to measure the... |
|
|
In vitro assessment of drug resistance in Plasmodium falciparum in five States of India.
Indian J. Med. Res. 135(4) , 494-9, (2012) In vitro assays are an important tool to assess baseline sensitivity and monitor the drug response of Plasmodium falciparum over time and place and, therefore, can provide background information for the development and evaluation of drug policies. This study ... |
|
|
Validation of high performance liquid chromatography–electrochemical detection methods with simultaneous extraction procedure for the determination of artesunate, dihydroartemisinin, amodiaquine and desethylamodiaquine in human plasma for application in clinical pharmacological studies of artesunate–amodiaquine drug combination
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 877(5-6) , 558-62, (2009) With the expanded use of the combination of artesunate (AS) and amodiaquine (AQ) for the treatment of falciparum malaria and the abundance of products on the market, comes the need for rapid and reliable bioanalytical methods for the determination of the pare... |
|
|
Pharmacokinetics and pharmacodynamics of a new ACT formulation: Artesunate/Amodiaquine (TRIMALACT) following oral administration in African malaria patients.
Eur. J. Drug Metab. Pharmacokinet. 34(3-4) , 133-42, (2009) A new fixed-dose combination of artesunate (AS) plus amodiaquine (AQ) (TRIMALACT) was recently developed for the treatment of uncomplicated falciparum malaria. The originality of this combination lies in its galenic formulation which consists of a three-layer... |
|
|
Determination of N-desethylamodiaquine by hydrophilic interaction liquid chromatography with tandem mass spectrometry: application to in vitro drug metabolism studies.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 863(1) , 129-34, (2008) The antimalarial drug amodiaquine is extensively metabolized to N-desethylamodiaquine (DEAQ) by cytochrome P450 2C8 (CYP2C8). DEAQ formation is an enzyme specific reaction that is used to quantify in vitro CYP2C8 activity. A rapid and sensitive method for the... |
|
|
Simultaneous determination of amodiaquine and its active metabolite in human blood by ion-pair liquid chromatography-tandem mass spectrometry.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 860(1) , 18-25, (2007) A sensitive and selective ion-pair liquid chromatography-tandem mass spectrometric method (IP-LC-MS/MS) for the simultaneous determination of amodiaquine (AQ) and its active metabolite, N-desethylamodiaquine (AQm), in human blood has been developed and valida... |
|
|
Biological measure of compliance to Artesunate plus Amodiaquine association: Interest in a Mono-Desethyl-Amodiaquine blood assay?
Acta Trop. 110(1) , 1-6, (2009) The deployment of Artemisinin-based Combination Therapy for treating uncomplicated malaria poses problems in the patient compliance to these new treatments. The aim of our study was to investigate the relationship between compliance to 3 days treatment with A... |
|
|
Studies on antimalarial drug susceptibility in Colombia, in relation to Pfmdr1 and Pfcrt.
Parasitology 135(5) , 547-53, (2008) In Colombia, Plasmodium resistance to antimalarials such as chloroquine and antifolates is a serious problem. As a result, the national Colombian health authorities are monitoring the efficacy of alternative drugs and schemes. The study of genetic polymorphis... |
|
|
In-vitro inhibitory effect of Tualang honey on cytochrome P450 2C8 activity.
J. Pharm. Pharmacol. 64(12) , 1761-9, (2012) To investigate the effect of Tualang honey on cytochrome P450 2C8 (CYP2C8) activity in vitro using an amodiaquine N-desethylase assay.CYP2C8 and NADPH cytochrome P450 reductase was cotransformed, expressed and harvested. The incubation assay contained express... |