二苯并(A,L)芘
二苯并(A,L)芘结构式
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常用名 | 二苯并(A,L)芘 | 英文名 | Dibenzo[a,l]pyrene |
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| CAS号 | 191-30-0 | 分子量 | 302.368 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 552.3±17.0 °C at 760 mmHg | |
| 分子式 | C24H14 | 熔点 | 162.4ºC | |
| MSDS | 中文版 美版 | 闪点 | 282.0±15.1 °C | |
| 符号 |
GHS05, GHS08 |
信号词 | Danger |
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In vitrometabolism of benzo[a]pyrene and dibenzo[def,p]chrysene in rodent and human hepatic microsomes
Toxicol. Lett. 228(1) , 48-55, (2014) • PAH clearance was highest in naïve female mice and lowest in female humans. • PAH clearance rates in male rat were more similar to female human than female mice. • Metabolism of B[a]P was generally more rapid than DBC, regardless of organism. • DBC metaboli... |
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Polycyclic aromatic hydrocarbons stimulate human CYP3A4 promoter activity via PXR.
Toxicol. Lett. 222(2) , 180-8, (2013) Metabolic activation of polycyclic aromatic hydrocarbons (PAH) is mediated mainly by cytochrome P₄₅₀ monooxygenases (CYP) CYP1A1, 1A2 and 1B1. Several PAH are known to induce these CYP via aryl hydrocarbon receptor (AhR) signaling. Recently, it was shown that... |
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The rainbow trout liver cancer model: Response to environmental chemicals and studies on promotion and chemoprevention
Comp. Biochem. Physiol. C. Toxicol. Pharmacol. 155(1) , 121-7, (2012) Rainbow trout ( Oncorhynchus mykiss) are an outstanding model of liver cancer induction by environmental chemicals and development of strategies for chemoprevention. Trout have critical and unique advantages allowing for cancer studies with 40,000 animals to ... |
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The influence of diesel exhaust on polycyclic aromatic hydrocarbon-induced DNA damage, gene expression, and tumor initiation in Sencar mice in vivo.
Cancer Lett. 265(1) , 135-47, (2008) The carcinogenic effects of individual polycyclic aromatic hydrocarbons (PAH) are well established. However, their potency within an environmental complex mixture is uncertain. We evaluated the influence of diesel exhaust particulate matter on PAH-induced cyt... |
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Dibenzo[def,p]chrysene (DBC) suppresses antibody formation in spleen cells following oral exposures of mice.
J. Toxicol. Environ. Health A 76(1) , 16-24, (2013) Dibenzo[def,p]chrysene (DBC) is a potent environmental carcinogen in rodents, fish, and human cells examined in culture. There are numerous similarities between the patterns of cytochrome P-450 (P450) activation of DBC and its covalent binding to DNA and prot... |
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Nuclear magnetic resonance solution structure of an N(2)-guanine DNA adduct derived from the potent tumorigen dibenzo[a,l]pyrene: intercalation from the minor groove with ruptured Watson-Crick base pairing.
Biochemistry 51(48) , 9751-62, (2012) The most potent tumorigen identified among the polycyclic aromatic hydrocarbons (PAH) is the nonplanar fjord region dibenzo[a,l]pyrene (DB[a,l]P). It is metabolically activated in vivo through the widely studied diol epoxide (DE) pathway to form covalent addu... |
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Cancer chemoprevention by dietary chlorophylls: a 12,000-animal dose-dose matrix biomarker and tumor study.
Food Chem. Toxicol. 50(2) , 341-52, (2012) Recent pilot studies found natural chlorophyll (Chl) to inhibit carcinogen uptake and tumorigenesis in rodent and fish models, and to alter uptake and biodistribution of trace (14)C-aflatoxin B1 in human volunteers. The present study extends these promising f... |
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Chemoprevention of dibenzo[a,l]pyrene transplacental carcinogenesis in mice born to mothers administered green tea: primary role of caffeine.
Carcinogenesis 29(8) , 1581-6, (2008) Our laboratory recently developed a mouse model of transplacental induction of lymphoma, lung and liver cancer by the polycyclic aromatic hydrocarbon, dibenzo[a,l]pyrene (DBP). Pregnant B6129SF1 females, bred to 129S1/SvIm males, were treated on day 17 of ges... |
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Identifying efficacious approaches to chemoprevention with chlorophyllin, purified chlorophylls and freeze-dried spinach in a mouse model of transplacental carcinogenesis.
Carcinogenesis 30(2) , 315-20, (2009) The carcinogenic potential of dibenzo[a,l]pyrene (DBP) has been well characterized in numerous animal models. We have previously documented that a single dose of 15 mg/Kg DBP to pregnant mice late in gestation (GD 17) produces an aggressive T-cell lymphoma as... |
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Association between mutation spectra and stable and unstable DNA adduct profiles in Salmonella for benzo[a]pyrene and dibenzo[a,l]pyrene.
Mutat. Res. 714(1-2) , 17-25, (2011) Benzo[a]pyrene (BP) and dibenzo[a,l]pyrene (DBP) are two polycyclic aromatic hydrocarbons (PAHs) that exhibit distinctly different mutagenicity and carcinogenicity profiles. Although some studies show that these PAHs produce unstable DNA adducts, conflicting ... |