纳洛芬
纳洛芬结构式
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常用名 | 纳洛芬 | 英文名 | nalorphine hydrochloride ciii (250 mg) |
|---|---|---|---|---|
| CAS号 | 57-29-4 | 分子量 | 347.83600 | |
| 密度 | N/A | 沸点 | 493.6ºC at 760 mmHg | |
| 分子式 | C19H22ClNO3 | 熔点 | 208ºC | |
| MSDS | N/A | 闪点 | 11ºC | |
| 符号 |
GHS02, GHS06, GHS08 |
信号词 | Danger |
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Analysis of naltrexone and its metabolite 6-beta-naltrexol in serum with high-performance liquid chromatography.
BMC Res. Notes 5 , 439, (2012) Naltrexone has been proven to be an effective treatment option for the treatment of alcohol dependency. In this article we introduce a reliable and simple method developed for the simultaneous determination of naltrexone and 6-β-naltrexol in human serum by us... |
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GC-MS confirmation of codeine, morphine, 6-acetylmorphine, hydrocodone, hydromorphone, oxycodone, and oxymorphone in urine.
J. Anal. Toxicol. 23(3) , 177-86, (1999) A procedure for the simultaneous confirmation of codeine, morphine, 6-acetylmorphine, hydrocodone, hydromorphone, oxycodone, and oxymorphone in urine specimens by gas chromatography-mass spectrometry (GC-MS) is described. After the addition of nalorphine and ... |
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Comparison of stably expressed rat UGT1.1 and UGT2B1 in the glucuronidation of opioid compounds.
Drug Metab. Dispos. 25(2) , 251-5, (1997) Opioids are important drugs used as analgesics, antitussives, antidiarrheals, and in the therapy of myocardial infarctions, and as antagonists of opioid intoxication. The glucuronidation of these compounds, catalyzed by UDP-glucuronosyltransferases (UGTs), is... |
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The mu opioid irreversible antagonist beta-funaltrexamine differentiates the discriminative stimulus effects of opioids with high and low efficacy at the mu opioid receptor.
Psychopharmacology 140 , 20, (1998) The purpose of the present study was to determine the relative intrinsic efficacy of various opioids using the irreversible mu opioid antagonist beta-funaltrexamine (betaFNA). To this end, pigeons were trained to discriminate 3.0 (n=6) or 1.8 (n=1) mg/kg morp... |
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The glucuronidation of exogenous and endogenous compounds by stably expressed rat and human UDP-glucuronosyltransferase 1.1.
Arch. Biochem. Biophys. 332(1) , 92-100, (1996) Rat and human UDP-glucuronosyltransferase (UGT) 1.1 share > 70% identity in their deduced primary amino acid sequences. We have previously shown that rat UGT1.1, stably expressed in human embryonic kidney 293 cells, catalyzes the glucuronidation of bilirubin ... |
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Social and environmental enrichment enhances sensitivity to the effects of kappa opioids: studies on antinociception, diuresis and conditioned place preference.
Pharmacol. Biochem. Behav. 76(1) , 93-101, (2003) Previous studies have reported that social and environmental enrichment can have a marked impact on the functional maturation of the central nervous system and may influence an organism's sensitivity to psychotropic drugs. The purpose of the present study was... |
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Discriminative stimulus effects of two doses of fentanyl in rats: pharmacological selectivity and effect of training dose on agonist and antagonist effects of mu opioids.
Psychopharmacology 148(2) , 136-45, (2000) Discriminative stimulus effects of mu opioids vary systematically as a function of training dose. Differences among training doses may arise from multiple mechanisms.In vivo apparent pA(2) analyses were used to examine the contributions of opioid mechanisms t... |
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Agonist regulation of the expression of the delta opioid receptor in NG108-15 cells.
FEBS Lett. 376(1-2) , 11-4, (1995) Exposure of neuronal cells to the chronic presence of opiates leads to a complex series of biochemical events which reflect the changes that result in tolerance and dependence in animals. To achieve a better understanding of the molecular mechanisms underlyin... |
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Differential antagonism of the rate-decreasing effects of kappa-opioid receptor agonists by naltrexone and norbinaltorphimine.
Eur. J. Pharmacol. 377 , 21-28, (1999) Eight kappa-opioid receptor agonists were examined for their effects in squirrel monkeys responding under a fixed interval 3-min schedule of stimulus termination. Six of these kappa-opioid receptor agonists decreased dose-dependently the total number of respo... |
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Nalorphine's ability to substitute for morphine in a drug discrimination procedure is a function of training dose.
Pharmacol. Biochem. Behav. 63 , 481, (1999) Rats trained to discriminate the mu agonists fentanyl or morphine from their respective vehicles generalize to the partial mu agonist nalorphine incompletely and inconsistently. Any number of factors may influence the generalization patterns obtained, one of ... |