SC-236
SC-236结构式
|
常用名 | SC-236 | 英文名 | SC-236 |
|---|---|---|---|---|
| CAS号 | 170569-86-5 | 分子量 | 401.791 | |
| 密度 | 1.5±0.1 g/cm3 | 沸点 | 543.4±60.0 °C at 760 mmHg | |
| 分子式 | C16H11ClF3N3O2S | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 282.4±32.9 °C | |
| 符号 |
GHS06 |
信号词 | Danger |
|
Downregulation of sphingosine 1-phosphate (S1P) receptor 1 by dexamethasone inhibits S1P-induced mesangial cell migration.
Biol. Chem. 396 , 803-12, (2015) Sphingosine 1-phosphate (S1P) is generated by sphingosine kinase (SK)-1 and -2 and acts mainly as an extracellular ligand at five specific receptors, denoted S1P1-5. After activation, S1P receptors regulate important processes in the progression of renal dise... |
|
|
Inhibition of COX-1 attenuates the formation of thromboxane A2 and ameliorates the acute decrease in glomerular filtration rate in endotoxemic mice.
Am. J. Physiol. Renal Physiol. 309 , F332-40, (2015) Thromboxane (Tx) A2 has been suggested to be involved in the development of sepsis-induced acute kidney injury (AKI). Therefore, we investigated the impact of cyclooxygenase (COX)-1 and COX-2 activity on lipopolysaccharide (LPS)-induced renal TxA2 formation, ... |
|
|
COX-2 gene dosage-dependent defects in kidney development.
Am. J. Physiol. Renal Physiol. 310 , F1113-22, (2016) Deletion of cyclooxygenase (COX)-2 causes impairment of kidney development, including hypothrophic glomeruli and cortical thinning. A critical role for COX-2 is seen 4-8 days postnatally. The present study was aimed at answering whether different COX-2 gene d... |