硫辛酸
硫辛酸结构式
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常用名 | 硫辛酸 | 英文名 | α-Lipoic Acid |
|---|---|---|---|---|
| CAS号 | 1077-28-7 | 分子量 | 206.326 | |
| 密度 | 1.2±0.1 g/cm3 | 沸点 | 362.5±11.0 °C at 760 mmHg | |
| 分子式 | C8H14O2S2 | 熔点 | 60-62ºC | |
| MSDS | 中文版 美版 | 闪点 | 173.0±19.3 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Identification and Characterization of EDTA Test Strip Interfering Substances Using a Digital Color Detector.
Clin. Lab. 61 , 785-91, (2015) Rapid test strips for ethylenediaminetetraacetic acid (EDTA) can be used to verify correct specimen types for clinical assays which require, or cannot be performed on, plasma collection tubes containing EDTA anticoagulant. As the test strip reaction chemistry... |
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Alpha-lipoic acid activates eNOS through activation of PI3-kinase/Akt signaling pathway.
Vascul. Pharmacol. 64 , 28-35, (2015) Lipoic acid (LA) exerts therapeutic effects on cardiovascular diseases. However, the mechanisms underlying these therapeutic effects remain elusive. Endothelial nitric oxide synthase (eNOS) plays a critical role in cardiovascular homeostasis. LA was shown to ... |
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All-trans retinoic acid prevents oxidative stress-induced loss of renal tight junction proteins in type-1 diabetic model.
J. Nutr. Biochem. 26 , 441-54, (2015) We previously reported that diabetes decreased the expression of renal tight junction (TJ) proteins claudin-5 in glomerulus, and claudin-2 and occludin in proximal tubule through an oxidative stress dependent way. Now we investigated whether all-trans retinoi... |
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Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
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Fluorescence Imaging Assisted Photodynamic Therapy Using Photosensitizer-Linked Gold Quantum Clusters.
ACS Nano 9 , 5825-32, (2015) Fluorescence imaging assisted photodynamic therapy (PDT) is a viable two-in-one clinical tool for cancer treatment and follow-up. While the surface plasmon effect of gold nanorods and nanoparticles has been effective for cancer therapy, their emission propert... |
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A novel drug delivery system of gold nanorods with doxorubicin and study of drug release by single molecule spectroscopy.
J. Drug Target. 23(1) , 52-8, (2014) The work presented here describes the fabrication of a novel drug delivery system, which consists of gold nanorods and doxorubicin, with the attachment of thioctic acid and folic acid, for the targeted release of drug to cancer cells. Doxorubicin, the potent ... |
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Cytotoxicity of gold nanoclusters in human liver cancer cells.
Int. J. Nanomedicine 9 , 5441-8, (2014) In this study, we synthesized water-soluble fluorescent gold nanoclusters (Au NCs) stabilized with dihydrolipoic acid (DHLA). The cytotoxicity of these Au NCs was then assessed in the normal human hepatic cell line (L02) and the human hepatoma cell line (HepG... |
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Compact and blinking-suppressed quantum dots for single-particle tracking in live cells.
J. Phys. Chem. B 118(49) , 14140-7, (2014) Quantum dots (QDs) offer distinct advantages over organic dyes and fluorescent proteins for biological imaging applications because of their brightness, photostability, and tunability. However, a major limitation is that single QDs emit fluorescent light in a... |
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A small molecule with anticancer and antimetastatic activities induces rapid mitochondrial-associated necrosis in breast cancer.
J. Pharmacol. Exp. Ther. 353(2) , 392-404, (2015) Therapy for treatment-resistant breast cancer provides limited options and the response rates are low. Therefore, the development of therapies with alternative chemotherapeutic strategies is necessary. AG311 (5-[(4-methylphenyl)thio]-9H-pyrimido[4,5-b]indole-... |
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Stability of a liposomal formulation containing lipoyl or dihydrolipoyl acylglycerides.
J. Liposome Res. 24(4) , 304-12, (2014) The acylglycerides of lipoic and dihydrolipoic acids may serve as slow-release sources for cutaneous delivery of these antioxidants when formulated in a liposomal vehicle.Testing was conducted to determine the storage stability of lipoyl glycerides in phospho... |