亚铁稳定化血红蛋白 A0 人
亚铁稳定化血红蛋白 A0 人结构式
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常用名 | 亚铁稳定化血红蛋白 A0 人 | 英文名 | Hemoglobin A0, Ferrous Stabilized, human |
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| CAS号 | 54651-57-9 | 分子量 | N/A | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | N/A | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | N/A |
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Isolated Hb Providence β82Asn and β82Asp fractions are more stable than native HbA(0) under oxidative stress conditions.
Biochemistry 50(45) , 9752-66, (2011) We have previously shown that hydrogen peroxide (H(2)O(2)) triggers irreversible oxidation of amino acids exclusive to the β-chains of purified human hemoglobin (HbAo). However, it is not clear, whether α- or β-subunit Hb variants exhibit different oxidative ... |
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Comparison of capillary electrophoregram among heterozygous Hb Hope, Hb Hope/α-thalassemia-1 SEA type deletion and Hb Hope/β(0)-thalassemia.
Clin. Chem. Lab Med. 50(9) , 1625-9, (2012) Hemoglobin (Hb) A(2) is artifactually elevated in cases of heterozygous Hb Hope when measured by capillary electrophoresis (CE). However, there is no report of HbA(2) levels and capillary electrophoregrams for associations of heterozygote of Hb Hope with α-th... |
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Effect of glycation of hemoglobin on its interaction with trifluoperazine.
Protein J. 25(3) , 202-11, (2006) Trifluoperazine (TFZ), a phenothiazine drug, penetrates into human erythrocytes and releases oxygen by interaction with hemoglobin. TFZ-induced oxygen release from hyperglycemic erythrocytes isolated from diabetic patients is considerably less compared to tha... |
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Human hemoglobin shares bioactivities ascribed to human tumor necrosis factor-alpha.
Immunopharmacol. Immunotoxicol. 26(4) , 559-72, (2004) Hemoglobin mediated cytotoxicity and apoptosis has been evaluated in Tumor necrosis factor-alpha (TNF-alpha) sensitive cell line, U937 and compared with TNF-alpha. Both species of hemoglobin, Hemoglobin A2 and Hemoglobin A0 induced apoptosis and cytotoxicity ... |
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Chromatographic removal of endotoxin from hemoglobin preparations. Effects of solution conditions on endotoxin removal efficiency and protein recovery.
J. Chromatogr. A. 809(1-2) , 13-20, (1998) In this work, affinity chromatography was used to remove endotoxin from human hemoglobin preparations with a Sterogene Acticlean Etox column. The effects of solution conditions on endotoxin removal efficiency and protein recovery have been investigated. It ha... |
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Reaction of human hemoglobin HbA0 and two cross-linked derivatives with hydrogen peroxide: differential behavior of the ferryl intermediate.
Arch. Biochem. Biophys. 316(1) , 461-9, (1995) Functional concerns regarding hemoglobin-based red cell substitutes have generally centered on two parameters: (a) oxygen binding and delivery properties and (b) stabilization of the hemoglobin tetramer to prevent dimerization. Strategic chemical cross-linkin... |
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Interactions of hemoglobin with hydrogen peroxide alters thiol levels and course of endothelial cell death.
Am. J. Physiol. Heart Circ. Physiol. 279(4) , H1880-9, (2000) We investigated cellular injury and death induced by ultrapure human Hb (HbA(0)) and its diaspirin cross-linked derivative DBBF-Hb in normal and glutathione (GSH)-depleted bovine aortic endothelial cells subjected to hydrogen peroxide (H(2)O(2)). HbA(0) under... |
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A novel function of extraerythrocytic hemoglobin: identification of globin as a stimulant of plasminogen activator biosynthesis in human fibroblasts.
Thromb. Haemost. 86(6) , 1521-7, (2001) Following wounding, the surrounding fibroblasts migrate towards the clotted blood in the wounded space to form granulation tissue resulting in wound repair. One of the most abundant proteins in the wound is hemoglobin (Hb). The aim of the present study was to... |
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Hemoglobin A0 and alpha-crosslinked hemoglobin (alpha-DBBF) potentiate agonist-induced platelet aggregation through the platelet thromboxane receptor.
Artif. Cells Blood Substit. Immobil. Biotechnol. 26(1) , 1-16, (1998) Chemically modified hemoglobins are potential oxygen-carrying blood substitutes, but their in vivo administration has been associated with a variety of unexpected side events, including increased platelet reactivity. We studied the effects of hemoglobin A0 (H... |
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The Bohr effect of hemoglobin intermediates and the role of salt bridges in the tertiary/quaternary transitions.
J. Biol. Chem. 276(17) , 13628-34, (2001) Understanding mechanisms in cooperative proteins requires the analysis of the intermediate ligation states. The release of hydrogen ions at the intermediate states of native and chemically modified hemoglobin, known as the Bohr effect, is an indicator of the ... |