1,2,3,6-四氢-4-吡啶甲酸盐酸盐
1,2,3,6-四氢-4-吡啶甲酸盐酸盐结构式
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常用名 | 1,2,3,6-四氢-4-吡啶甲酸盐酸盐 | 英文名 | Isoguvacine Hydrochloride |
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| CAS号 | 68547-97-7 | 分子量 | 163.60200 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C6H10ClNO2 | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | N/A | |
| 符号 |
GHS07 |
信号词 | Warning |
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A molecular characterization of the agonist binding site of a nematode cys-loop GABA receptor.
Br. J. Pharmacol. 172 , 3737-47, (2015) Cys-loop GABA receptors represent important targets for human chemotherapeutics and insecticides and are potential targets for novel anthelmintics (nematicides). However, compared with insect and mammalian receptors, little is known regarding the pharmacologi... |
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The Kölliker-Fuse nucleus gates the postinspiratory phase of the respiratory cycle to control inspiratory off-switch and upper airway resistance in rat.
Eur. J. Neurosci. 24(4) , 1071-84, (2006) Lesion or pharmacological manipulation of the dorsolateral pons can transform the breathing pattern to apneusis (pathological prolonged inspiration). Apneusis reflects a disturbed inspiratory off-switch mechanism (IOS) leading to a delayed phase transition fr... |
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Subthalamic stimulation evokes complex EPSCs in the rat substantia nigra pars reticulata in vitro.
J. Physiol. 573(Pt 3) , 697-709, (2006) The subthalamic nucleus (STN) plays an important role in movement control by exerting its excitatory influence on the substantia nigra pars reticulata (SNR), a major output structure of the basal ganglia. Moreover, excessive burst firing of SNR neurons seen i... |
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Inhibitory actions of the gamma-aminobutyric acid in pediatric Sturge-Weber syndrome.
Ann. Neurol. 66(2) , 209-18, (2009) The mechanisms of epileptogenesis in Sturge-Weber syndrome (SWS) are unknown. We explored the properties of neurons from human pediatric SWS cortex in vitro and tested in particular whether gamma-aminobutyric acid (GABA) excites neurons in SWS cortex, as has ... |
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Anticonvulsant action of GABA in the high potassium-low magnesium model of ictogenesis in the neonatal rat hippocampus in vivo and in vitro.
J. Neurophysiol. 94(4) , 2987-92, (2005) Previous developmental studies in vitro suggested that the inhibitory neurotransmitter GABA exerts depolarizing and excitatory actions on the immature neurons and that depolarizing GABA is causally linked to ictal activity during the first weeks of postnatal ... |
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Regulation of cardiac sympathetic afferent reflex by GABA(A) and GABA(B) receptors in paraventricular nucleus in rats.
Eur. J. Neurosci. 27(12) , 3226-32, (2008) The aim of the present study was to determine the role of GABA(A) and GABA(B) receptors in paraventricular nucleus (PVN) in regulating cardiac sympathetic afferent reflex (CSAR). Under urethane (800 mg/kg) and alpha-chloralose (40 mg/kg) anesthesia, renal sym... |
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Potentiating effect of eszopiclone on GABA(A) receptor-mediated responses in pedunculopontine neurons.
Sleep 32(7) , 879-87, (2009) The pedunculopontine nucleus (PPN) is part of the cholinergic arm of the reticular activating system, which is mostly active during waking and REM sleep. GABAergic modulation of this area appears to regulate sleep-wake cycles. Eszopiclone (ESZ), a nonbenzodia... |
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Regulation of spike timing-dependent plasticity of olfactory inputs in mitral cells in the rat olfactory bulb.
PLoS ONE 7(4) , e35001, (2012) The recent history of activity input onto granule cells (GCs) in the main olfactory bulb can affect the strength of lateral inhibition, which functions to generate contrast enhancement. However, at the plasticity level, it is unknown whether and how the prior... |
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Insights into GABA receptor signalling in TM3 Leydig cells.
Neuroendocrinology 81(6) , 381-90, (2005) Gamma-aminobutyric acid (GABA) is an emerging signalling molecule in endocrine organs, since it is produced by endocrine cells and acts via GABA(A) receptors in a paracrine/autocrine fashion. Testicular Leydig cells are producers and targets for GABA. These c... |
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Modulation of anticonvulsant effects of cannabinoid compounds by GABA-A receptor agonist in acute pentylenetetrazole model of seizure in rat.
Neurochem. Res. 36(8) , 1520-5, (2011) Cannabinoid system plays an important role in controlling neuronal excitability and brain function. On the other hand, modulation of gamma-aminobutyric acid (GABA) transmission is one of the initial strategies for the treatment of seizure. The aim of the pres... |