布洛芬酰基葡糖苷酸
布洛芬酰基葡糖苷酸结构式
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常用名 | 布洛芬酰基葡糖苷酸 | 英文名 | Ibuprofen Acyl-b-D-glucuronide |
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| CAS号 | 115075-59-7 | 分子量 | 382.40500 | |
| 密度 | 1.34g/cm3 | 沸点 | 567.3ºC at 760 mmHg | |
| 分子式 | C19H26O8 | 熔点 | 26-28ºC | |
| MSDS | 美版 | 闪点 | 198.3ºC |
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Direct determination of ibuprofen and ibuprofen acyl glucuronide in plasma by high-performance liquid chromatography using solid-phase extraction.
J. Chromatogr. A. 614(1) , 109-16, (1993) A method for the simultaneous determination of ibuprofen and its labile, reactive metabolite, ibuprofen acyl glucuronide, in plasma is described. Reversed-phase high-performance liquid chromatography (HPLC) employed a C18 column using methanol-10 mM trifluoro... |
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Disposition and reactivity of ibuprofen and ibufenac acyl glucuronides in vivo in the rhesus monkey and in vitro with human serum albumin.
Drug Metab. Dispos. 23(5) , 566-72, (1995) The disposition of ibuprofen and ibufenac, an analog of ibuprofen with a history of severe adverse reactions, was investigated in Rhesus monkeys after oral administration. Plasma concentrations of the parent drugs and their glucuronides were measured by a dir... |
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Stereoselective Inhibition of Methotrexate Excretion by Glucuronides of Nonsteroidal Anti-inflammatory Drugs via Multidrug Resistance Proteins 2 and 4.
J. Pharmacol. Exp. Ther. 356 , 366-74, (2016) Combined administration of methotrexate (MTX) and nonsteroidal anti-inflammatory drugs (NSAIDs) can result in a decreased systemic clearance of MTX. To date, inhibition of renal uptake via organic anion transporters and efflux via multidrug resistance-associa... |
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Disposition and covalent binding of ibuprofen and its acyl glucuronide in the elderly.
Clin. Pharmacol. Ther. 57(6) , 636-44, (1995) Ibuprofen is an over-the-counter nonsteroidal anti-inflammatory drug with a low incidence of severe adverse reactions. It is metabolized by oxidation to carboxyibuprofen and hydroxyibuprofen and by conjugation to an acyl glucuronide. In vitro studies have ind... |
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Enhanced performance in the determination of ibuprofen 1-β-O-acyl glucuronide in urine by combining high field asymmetric waveform ion mobility spectrometry with liquid chromatography-time-of-flight mass spectrometry.
J. Chromatogr. A. 1278 , 76-81, (2013) The incorporation of a chip-based high field asymmetric waveform ion mobility spectrometry (FAIMS) separation in the ultra (high)-performance liquid chromatography-high resolution mass spectrometry (UHPLC-HRMS) determination of the (R/S) ibuprofen 1-β-O-acyl ... |
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NMR spectroscopic studies of the transacylation reactivity of ibuprofen 1-beta-O-acyl glucuronide.
J. Pharm. Biomed. Anal. 41(3) , 1002-6, (2006) The products arising from the intra-molecular acyl migration reactions of drug ester glucuronides can be reactive towards cellular proteins and have been proposed to cause toxic side effects. The relative reactivity of a range of drug and model glucuronides h... |