盐酸洛美利嗪
盐酸洛美利嗪结构式
|
常用名 | 盐酸洛美利嗪 | 英文名 | Lomerizine hydrochloride |
|---|---|---|---|---|
| CAS号 | 101477-54-7 | 分子量 | 541.457 | |
| 密度 | N/A | 沸点 | 527.3ºC at760mmHg | |
| 分子式 | C27H32Cl2F2N2O3 | 熔点 | 214-218ºC | |
| MSDS | 中文版 美版 | 闪点 | 272.7ºC | |
| 符号 |
GHS07, GHS09 |
信号词 | Warning |
|
A screen of approved drugs and molecular probes identifies therapeutics with anti-Ebola virus activity.
Sci. Transl. Med. 7 , 290ra89, (2015) Currently, no approved therapeutics exist to treat or prevent infections induced by Ebola viruses, and recent events have demonstrated an urgent need for rapid discovery of new treatments. Repurposing approved drugs for emerging infections remains a critical ... |
|
|
Neuroprotection by lomerizine, a prophylactic drug for migraine, against hydrogen peroxide-induced hippocampal neurotoxicity.
Mol. Cell Biochem. 358(1-2) , 1-11, (2011) Migraine is one of the risk factor for ischemic stroke. The purpose of this study was to examine the effect of lomerizine, a prophylactic drug for migraine, on H(2)O(2)-induced cell death of hippocampal neurons. Cytosolic Ca(2+) concentration was measured usi... |
|
|
Goshuyuto, a traditional Japanese medicine for migraine, inhibits platelet aggregation in guinea-pig whole blood.
J. Pharmacol. Sci. 108(1) , 89-94, (2008) The effects of goshuyuto and chotosan, traditional Japanese medicines, on collagen-induced platelet aggregation were examined using guinea-pig blood. Goshuyuto at the concentration of 1,000 mug/mL inhibited collagen-induced platelet hyper-aggregation to the s... |
|
|
CJZ3, a lomerizine derivative, modulates P-glycoprotein function in rat brain microvessel endothelial cells.
Acta Pharmacol. Sin. 27(4) , 414-8, (2006) To investigate the modulatory effect of CJZ3, a lomerizine derivative, on P-glycoprotein (P-gp) function in rat brain microvessel endothelial cells (RBMEC).RBMEC were isolated and cultured in Dulbecco modified Eagle medium/F12 (1:1) medium, and the amount of ... |
|
|
A new calcium channel antagonist, lomerizine, alleviates secondary retinal ganglion cell death after optic nerve injury in the rat.
Curr. Eye Res. 31(3) , 273-83, (2006) We investigated whether lomerizine, a new diphenylmethylpiperazine calcium channel blocker, exerted a neuroprotective effect on axonal or retinal damage induced by optic nerve injury in the rat.A partial crush lesion was inflicted unilaterally on the optic ne... |
|
|
Increase in doxorubicin cytotoxicity by inhibition of P-glycoprotein activity with lomerizine.
Biol. Pharm. Bull. 24(5) , 555-7, (2001) Acquired resistance to chemotherapy is a major problem during cancer treatment. One mechanism for drug resistance is overexpression of the MDR (multidrug resistance)1 gene encoding the transmembrane efflux pump, P-glycoprotein (P-gp). Calcium channel blockers... |
|
|
Do the effects of long-term lomerizine administration differ with age?
Intern. Med. 46(10) , 683-4, (2007)
|
|
|
Short-lasting unilateral neuralgiform headache attacks with cranial autonomic symptoms (SUNA).
Intern. Med. 48(24) , 2141-4, (2009) Short-lasting unilateral neuralgiform headache attacks with cranial autonomic symptoms (SUNA) is a rare primary headache syndrome. The diagnostic criteria include attacks of unilateral orbital, supraorbital or temporal stabbing pain accompanied by one of the ... |
|
|
Cognitive impairment and cerebral hypoperfusion in a CADASIL patient improved during administration of lomerizine.
Clin. Neuropharmacol. 32(2) , 113-6, (2009) A 64-year-old woman was admitted to our hospital for recurrent stroke and cognitive impairment and was diagnosed with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). Iodine-123 iodoamphetamine single photo... |
|
|
Interaction of CJZ3, a lomerizine derivative, with ATPase activity of human P-glycoprotein in doxorubicin-resistant human myelogenous leukemia (K562/DOX) cells.
Pharmazie 65(7) , 515-9, (2010) P-Glycoprotein, a 170-180 kDa membrane glycoprotein that mediates multidrug resistance, hydrolyses ATP to efflux a broad spectrum of hydrophobic agents. To observe the interaction of a P-gp reversal agent with P-gp ATPase activity should provide further insig... |