扎达维林
扎达维林结构式
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常用名 | 扎达维林 | 英文名 | Zardaverine |
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| CAS号 | 101975-10-4 | 分子量 | 268.216 | |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | N/A | |
| 分子式 | C12H10F2N2O3 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | N/A |
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Uncovering caffeine's adenosine A2A receptor inverse agonism in experimental parkinsonism.
ACS Chem. Biol. 9(11) , 2496-501, (2014) Caffeine, the most consumed psychoactive substance worldwide, may have beneficial effects on Parkinson's disease (PD) therapy. The mechanism by which caffeine contributes to its antiparkinsonian effects by acting as either an adenosine A2A receptor (A2AR) neu... |
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Dopamine receptors D3 and D5 regulate CD4(+)T-cell activation and differentiation by modulating ERK activation and cAMP production.
J. Neuroimmunol. 284 , 18-29, (2015) Dopamine receptors have been described in T-cells, however their signalling pathways coupled remain unknown. Since cAMP and ERKs play key roles regulating T-cell physiology, we aim to determine whether cAMP and ERK1/2-phosphorylation are modulated by dopamine... |
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Phenotype-based screening of mechanistically annotated compounds in combination with gene expression and pathway analysis identifies candidate drug targets in a human squamous carcinoma cell model.
J. Biomol. Screen. 11(5) , 457-68, (2006) The squamous cell carcinoma HeLa cell line and an epithelial cell line hTERT-RPE with a nonmalignant phenotype were interrogated for HeLa cell selectivity in response to 1267 annotated compounds representing 56 pharmacological classes. Selective cytotoxic act... |
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The specific type III and IV phosphodiesterase inhibitor zardaverine suppresses formation of tumor necrosis factor by macrophages.
Eur. J. Pharmacol. 230(1) , 9-14, (1993) Murine resident peritoneal macrophages were stimulated with lipopolysaccharide and treated with phosphodiesterase (PDE) inhibitors zardaverine, rolipram and motapizone. The PDE inhibitors suppressed the formation of tumor necrosis factor (TNF) by macrophages.... |
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Crystal structure of phosphodiesterase 4D and inhibitor complex(1).
FEBS Lett. 530(1-3) , 53-8, (2002) Cyclic nucleotide phosphodiesterases (PDEs) regulate physiological processes by degrading intracellular second messengers, adenosine-3',5'-cyclic phosphate or guanosine-3',5'-cyclic phosphate. The first crystal structure of PDE4D catalytic domain and a bound ... |
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Effect of Isoenzyme Selective Phosphodiesterase Inhibitors on the Proliferation of Murine Thymus and Spleen Cells
Pulm. Pharmacol. 9(1) , 35-41, (1996) The effects of isoenzyme selective phosphodiesterase inhibitors on mitogen-stimulated proliferation of murine thymus and spleen cells was determined. The type 4 phosphodiesterase inhibitors, (rolipram, RO 20-1724 and denbufylline) and the mixed type 3/4 inhib... |
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Phosphodiesterase activity in neutrophils from horses with chronic obstructive pulmonary disease.
Vet. Immunol. Immunopathol. 76(3-4) , 319-30, (2000) Neutrophils are recruited to the lungs of horses with chronic obstructive pulmonary disease (COPD) and exhibit increased activity after antigen challenge. Phosphodiesterase type4 (PDE4) inhibitors have been shown to attenuate human neutrophil activation. The ... |
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Ion transport characteristics of the murine trachea and caecum.
Clin. Sci. 82(6) , 667-72, (1992) 1. The basic defect in cystic fibrosis relates to abnormalities of ion transport in affected tissues, such as the respiratory and gastrointestinal tracts. The identification of the cystic fibrosis gene has enabled studies on the production of a cystic fibrosi... |
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Hydrogen peroxide-induced increase in lung endothelial and epithelial permeability--effect of adenylate cyclase stimulation and phosphodiesterase inhibition.
Microvasc. Res. 50(1) , 1-17, (1995) Neutrophil-derived hydrogen peroxide (H2O2) is believed to play an important role in inflammatory lung injury. We investigated the influence of pharmacological agents that increase intracellular c-AMP levels on endothelial and epithelial leakage in response t... |
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Effects of the mixed phosphodiesterase III/IV inhibitor, zardaverine, on airway function in patients with chronic airflow obstruction.
Respir. Med. 89(6) , 441-4, (1995) Zardaverine is a selective inhibitor of phosphodiesterase (PDE) III and IV isozymes. It has been shown to exert potent bronchodilator effects in animals. In order to study the efficacy and safety in man, a phase II clinical trial in 10 patients with partially... |