扎达维林结构式
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常用名 | 扎达维林 | 英文名 | Zardaverine |
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CAS号 | 101975-10-4 | 分子量 | 268.216 | |
密度 | 1.4±0.1 g/cm3 | 沸点 | N/A | |
分子式 | C12H10F2N2O3 | 熔点 | N/A | |
MSDS | 中文版 美版 | 闪点 | N/A |
扎达维林用途Zardaverine是新型的PDE3和4抑制剂,IC50分别为0.5 uM和0.8 uM。 |
中文名 | 扎达维林 |
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英文名 | zardaverine |
中文别名 | 6-[4-(二氟甲氧基)-3-甲氧基苯基]-3(2H)-吡哒嗪酮 |
英文别名 | 更多 |
描述 | Zardaverine是新型的PDE3和4抑制剂,IC50分别为0.5 uM和0.8 uM。 |
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相关类别 | |
参考文献 |
密度 | 1.4±0.1 g/cm3 |
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分子式 | C12H10F2N2O3 |
分子量 | 268.216 |
精确质量 | 268.065948 |
PSA | 64.21000 |
LogP | 0.90 |
折射率 | 1.555 |
储存条件 | 2-8℃ |
计算化学 | 1.疏水参数计算参考值(XlogP):2.2 2.氢键供体数量:1 3.氢键受体数量:6 4.可旋转化学键数量:4 5.互变异构体数量:2 6.拓扑分子极性表面积:59.9 7.重原子数量:19 8.表面电荷:0 9.复杂度:398 10.同位素原子数量:0 11.确定原子立构中心数量:0 12.不确定原子立构中心数量:0 13.确定化学键立构中心数量:0 14.不确定化学键立构中心数量:0 15.共价键单元数量:1 |
个人防护装备 | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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危险品运输编码 | NONH for all modes of transport |
~% 扎达维林 101975-10-4 |
文献:US4665074 A1, ; |
扎达维林上游产品 1 | |
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扎达维林下游产品 0 |
Uncovering caffeine's adenosine A2A receptor inverse agonism in experimental parkinsonism.
ACS Chem. Biol. 9(11) , 2496-501, (2014) Caffeine, the most consumed psychoactive substance worldwide, may have beneficial effects on Parkinson's disease (PD) therapy. The mechanism by which caffeine contributes to its antiparkinsonian effec... |
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Dopamine receptors D3 and D5 regulate CD4(+)T-cell activation and differentiation by modulating ERK activation and cAMP production.
J. Neuroimmunol. 284 , 18-29, (2015) Dopamine receptors have been described in T-cells, however their signalling pathways coupled remain unknown. Since cAMP and ERKs play key roles regulating T-cell physiology, we aim to determine whethe... |
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Phenotype-based screening of mechanistically annotated compounds in combination with gene expression and pathway analysis identifies candidate drug targets in a human squamous carcinoma cell model.
J. Biomol. Screen. 11(5) , 457-68, (2006) The squamous cell carcinoma HeLa cell line and an epithelial cell line hTERT-RPE with a nonmalignant phenotype were interrogated for HeLa cell selectivity in response to 1267 annotated compounds repre... |
3-[4-(difluoromethoxy)-3-methoxyphenyl]-1H-pyridazin-6-one |
3-pyridazinol, 6-[4-(difluoromethoxy)-3-methoxyphenyl]- |
Zardaverine |
3(2H)-Pyridazinone, 6-[4-(difluoromethoxy)-3-methoxyphenyl]- |
6-[4-(Difluoromethoxy)-3-methoxyphenyl]-3(2H)-pyridazinone |
zardaverinum |
zardaverina |
6-[4-(Difluoromethoxy)-3-methoxyphenyl]pyridazin-3(2H)-one |