CGP-42112
CGP-42112结构式
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常用名 | CGP-42112 | 英文名 | Angiotensin II Receptor Ligand |
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| CAS号 | 127060-75-7 | 分子量 | 1052.185 | |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | N/A | |
| 分子式 | C52H69N13O11 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | N/A |
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Altered efficacy of AT1R-targeted treatment after spontaneous cancer cell-AT1R upregulation.
BMC Cancer 11 , 274, (2011) Targeting of the renin angiotensin system (RAS) reduces tumour growth in experimental models of cancer. We aimed to establish if combined targeting of the 'classical' and 'alternative' arms of the RAS could result in synergistic inhibition of colorectal cance... |
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Update on the angiotensin AT(2) receptor.
Curr. Hypertens. Rep. 15(1) , 25-30, (2013) It is quite well established that activation of the AT(2) receptor (AT(2)R) provides a counter-regulatory role to AT(1)R overactivity, particularly during pathological conditions. Indeed, a potential therapeutic role for the AT(2)R is currently being promulga... |
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Angiotensin III modulates the nociceptive control mediated by the periaqueductal gray matter
Neuroscience 164(3) , 1263-73, (2009) Endogenous angiotensin (Ang) II and/or an Ang II-derived peptide, acting on Ang type 1 (AT1) and Ang type 2 (AT2) receptors, can carry out part of the nociceptive control modulated by periaqueductal gray matter (PAG). However, neither the identity of this put... |
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Increased vascular angiotensin type 2 receptor expression and NOS-mediated mechanisms of vascular relaxation in pregnant rats.
Am. J. Physiol. Heart Circ. Physiol. 296(3) , H745-55, (2009) Normal pregnancy is associated with reduced blood pressure (BP) and decreased pressor response to vasoconstrictors, even though the renin-angiotensin system is upregulated. Angiotensin II (ANG II) activates both angiotensin type 1 receptors (AT(1)Rs) and angi... |
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Angiotensin II type 2 receptor vasoactivity in internal mammary arteries of patients with coronary artery disease.
J. Cardiovasc. Pharmacol. 50(4) , 372-9, (2007) Several animal studies suggested that the angiotensin II type 2 (AT2) receptor subtype mediates vasodilation, yet the results in human arteries are less well described and more inconsistent. Therefore, we evaluated the role of the AT2 receptor stimulation on ... |
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Angiotensin II AT(2) receptor decreases AT(1) receptor expression and function via nitric oxide/cGMP/Sp1 in renal proximal tubule cells from Wistar-Kyoto rats.
J. Hypertens. 30(6) , 1176-84, (2012) The renin-angiotensin (Ang) system controls blood pressure, in part, by regulating renal tubular sodium transport. In the kidney, activation of the angiotensin II type 1 (AT(1)) receptor increases renal sodium reabsorption, whereas the angiotensin II type 2 (... |
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Angiotensin II type 2 receptor-mediated inhibition of NaCl absorption is blunted in thick ascending limbs from Dahl salt-sensitive rats.
Hypertension 60(3) , 765-9, (2012) NO reduces NaCl absorption by thick ascending limbs (TALs) by inhibiting the Na/K/2Cl cotransporter (NKCC2). We have shown that NO-induced inhibition of Na transport is reduced in Dahl salt-sensitive rat (SS) TALs. Angiotensin II increases NO production in TA... |
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Angiotensin II Type-2 receptors modulate inflammation through signal transducer and activator of transcription proteins 3 phosphorylation and TNFα production.
J. Interferon Cytokine Res. 31(6) , 471-4, (2011) Angiotensin subtype-1 receptor (AT(1)R) influences inflammatory processes through enhancing signal transducer and activator of transcription proteins 3 (STAT3) signal transduction, resulting in increased tumor necrosis factor-α (TNF-α) production. Although an... |
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Acute and chronic angiotensin-(1-7) restores vasodilation and reduces oxidative stress in mesenteric arteries of salt-fed rats.
Am. J. Physiol. Heart Circ. Physiol. 301(4) , H1341-52, (2011) This study determined the effect of ANG-(1-7) on salt-induced suppression of endothelium-dependent vasodilatation in the mesenteric arteries of male Sprague-Dawley rats. Chronic intravenous infusion of ANG-(1-7), oral administration of the nonpeptide mas rece... |
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Angiotensin II AT2 receptor regulates ureteric bud morphogenesis.
Am. J. Physiol. Renal Physiol. 298(3) , F807-17, (2010) ANG II AT2 receptor (AT2R)-deficient mice exhibit abnormal ureteric bud (UB) budding, increased incidence of double ureters, and vesicoureteral reflux. However, the role of the AT2R during UB morphogenesis and the mechanisms by which aberrant AT2R signaling d... |