碳酰氰-4-三氟甲氧基苯腙
碳酰氰-4-三氟甲氧基苯腙结构式
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常用名 | 碳酰氰-4-三氟甲氧基苯腙 | 英文名 | FCCP |
|---|---|---|---|---|
| CAS号 | 370-86-5 | 分子量 | 254.168 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 293.3±50.0 °C at 760 mmHg | |
| 分子式 | C10H5F3N4O | 熔点 | 174-175ºC (dec.)(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 131.2±30.1 °C | |
| 符号 |
GHS06 |
信号词 | Danger |
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Muscle-specific Drp1 overexpression impairs skeletal muscle growth via translational attenuation.
Cell Death Dis. 6 , e1663, (2015) Mitochondrial fission and fusion are essential processes in the maintenance of the skeletal muscle function. The contribution of these processes to muscle development has not been properly investigated in vivo because of the early lethality of the models gene... |
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HC toxin (a HDAC inhibitor) enhances IRS1-Akt signalling and metabolism in mouse myotubes.
J. Mol. Endocrinol. 55 , 197-207, (2015) Exercise enhances numerous signalling pathways and activates substrate metabolism in skeletal muscle. Small molecule compounds that activate these cellular responses have been shown to recapitulate the metabolic benefits of exercise. In this study, a histone ... |
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NH2-truncated human tau induces deregulated mitophagy in neurons by aberrant recruitment of Parkin and UCHL-1: implications in Alzheimer's disease.
Hum. Mol. Genet. 24 , 3058-81, (2015) Disarrangement in functions and quality control of mitochondria at synapses are early events in Alzheimer's disease (AD) pathobiology. We reported that a 20-22 kDa NH2-tau fragment mapping between 26 and 230 amino acids of the longest human tau isoform (aka N... |
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Intracellular ROS Generation Mediates Maleimide-induced Cytotoxicity in Leukemia Cells.
Anticancer Agents Med. Chem. 15 , 1164-73, (2015) Maleimides consist of an important class of compounds easily synthesized with multiple functional group modification that provides expressive pharmacological properties including, antitumoral activity, mediated mainly by oxidative stress. For this reason, the... |
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Isoprenylcysteine carboxylmethyltransferase regulates mitochondrial respiration and cancer cell metabolism.
Oncogene 34 , 3296-304, (2015) Isoprenylcysteine carboxylmethyltransferase (Icmt) catalyzes the last of the three-step posttranslational protein prenylation process for the so-called CaaX proteins, which includes many signaling proteins, such as most small GTPases. Despite extensive studie... |
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Developing structure-activity relationships for the prediction of hepatotoxicity.
Chem. Res. Toxicol. 23 , 1215-22, (2010) Drug-induced liver injury is a major issue of concern and has led to the withdrawal of a significant number of marketed drugs. An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification o... |
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A predictive ligand-based Bayesian model for human drug-induced liver injury.
Drug Metab. Dispos. 38 , 2302-8, (2010) Drug-induced liver injury (DILI) is one of the most important reasons for drug development failure at both preapproval and postapproval stages. There has been increased interest in developing predictive in vivo, in vitro, and in silico models to identify comp... |
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C-phycocyanin prevents cisplatin-induced mitochondrial dysfunction and oxidative stress.
Mol. Cell Biochem. 406 , 183-97, (2015) The potential of C-phycocyanin (C-PC) to prevent cisplatin (CP)-induced kidney mitochondrial dysfunction was determined in CD-1 male mice. The CP-induced mitochondrial dysfunction was characterized by ultrastructural abnormalities and by decrease in the follo... |
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Organic anion transporting polypeptides and organic cation transporter 1 contribute to the cellular uptake of the flavonoid quercetin.
Naunyn Schmiedebergs Arch. Pharmacol. 387(9) , 883-91, (2014) Flavonoids such as quercetin and kaempferol mediate several health protective effects, e.g., anticancer effects. They are inhibitors of organic anion transporting polypeptides (OATP) and organic cation transporters (e.g., OCT2). However, little is known wheth... |
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Role of polyol moiety of amphotericin B in ion channel formation and sterol selectivity in bilayer membrane.
Bioorg. Med. Chem. 23 , 5782-8, (2015) Amphotericin B (AmB) is a polyene macrolide antibiotic widely used to treat mycotic infections. In this paper, we focus on the role of the polyol moiety of AmB in sterol selectivity using 7-oxo-AmB, 7α-OH-AmB, and 7β-OH-AmB. The 7-OH analogs were prepared fro... |