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15-脱氧-Δ12,14-前列腺素J2

15-脱氧-Δ12,14-前列腺素J2结构式
15-脱氧-Δ12,14-前列腺素J2结构式
品牌特惠专场
常用名 15-脱氧-Δ12,14-前列腺素J2 英文名 15-Deoxy-Delta12
CAS号 87893-55-8 分子量 316.435
密度 1.1±0.1 g/cm3 沸点 495.8±34.0 °C at 760 mmHg
分子式 C20H28O3 熔点 N/A
MSDS 美版 闪点 267.8±22.2 °C
符号 GHS02 GHS07
GHS02, GHS07
信号词 Danger

HMDB: a knowledgebase for the human metabolome.

Nucleic Acids Res. 37(Database issue) , D603-10, (2009)

The Human Metabolome Database (HMDB, http://www.hmdb.ca) is a richly annotated resource that is designed to address the broad needs of biochemists, clinical chemists, physicians, medical geneticists, nutritionists and members of the metabolomics community. Si...

The human serum metabolome.

PLoS ONE 6(2) , e16957, (2011)

Continuing improvements in analytical technology along with an increased interest in performing comprehensive, quantitative metabolic profiling, is leading to increased interest pressures within the metabolomics community to develop centralized metabolite ref...

Lipidomics reveals a remarkable diversity of lipids in human plasma.

J. Lipid Res. 51(11) , 3299-305, (2010)

The focus of the present study was to define the human plasma lipidome and to establish novel analytical methodologies to quantify the large spectrum of plasma lipids. Partial lipid analysis is now a regular part of every patient's blood test and physicians r...

Calcium-responsive transactivator (CREST) protein shares a set of structural and functional traits with other proteins associated with amyotrophic lateral sclerosis.

Molecular Neurodegeneration 10 , 20, (2015)

Mutations in calcium-responsive transactivator (CREST) encoding gene have been recently linked to ALS. Similar to several proteins implicated in ALS, CREST contains a prion-like domain and was reported to be a component of paraspeckles.We demonstrate that CRE...

Raphe-mediated signals control the hippocampal response to SRI antidepressants via miR-16.

Transl. Psychiatry 1 , e56, (2012)

Serotonin reuptake inhibitor (SRI) antidepressants such as fluoxetine (Prozac), promote hippocampal neurogenesis. They also increase the levels of the bcl-2 protein, whose overexpression in transgenic mice enhances adult hippocampal neurogenesis. However, the...

Rosiglitazone inhibits metastasis development of a murine mammary tumor cell line LMM3.

BMC Cancer 8 , 47, (2008)

Activation of peroxisome proliferator-activated receptors gamma (PPARgamma) induces diverse effects on cancer cells. The thiazolidinediones (TZDs), such as troglitazone and ciglitazone, are PPARgamma agonists exhibiting antitumor activities; however, the unde...

Fenretinide stimulates redox-sensitive ceramide production in breast cancer cells: potential role in drug-induced cytotoxicity.

Br. J. Cancer 91 , 1821-8, (2004)

The synthetic retinoid N-(4-hydroxphenyl) retinamide (4HPR) has manifold actions, which may contribute to its chemopreventive effects on breast cancer cell growth and progression. A role for ceramide as a stress-response signal is investigated here during the...

PPARdelta promotes wound healing by up-regulating TGF-beta1-dependent or -independent expression of extracellular matrix proteins.

J. Cell. Mol. Med. 14 , 1747-59, (2010)

Although the peroxisome proliferator-activated receptor (PPAR) delta has been implicated in the wound healing process, its exact role and mechanism of action have not been fully elucidated. Our previous findings showed that PPARdelta induces the expression of...

Biosynthesis of 15-deoxy-delta12,14-PGJ2 and the ligation of PPARgamma.

J. Clin. Invest. 112(6) , 945-55, (2003)

15-deoxy-Delta12,14-PGJ2 (15d-PGJ2) has been identified as an endogenous ligand for PPARgamma, inducing adipogenesis in vitro. Additional roles for this molecule in the propagation and resolution of inflammation, ligation of NF-kappaB, and mediation of apopto...

Lipidomic analysis of twenty-seven prostanoids and isoprostanes by liquid chromatography/electrospray tandem mass spectrometry.

Rapid Commun. Mass Spectrom. 20(20) , 3023-9, (2006)

Prostanoids are potent mediators of many physiological and pathophysiological processes. Of the many analytical methodologies used for their qualitative and quantitative analysis, electrospray tandem mass spectrometry coupled to liquid chromatography (LC/ESI-...