香叶木素
香叶木素结构式
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常用名 | 香叶木素 | 英文名 | Diosmetin |
|---|---|---|---|---|
| CAS号 | 520-34-3 | 分子量 | 300.263 | |
| 密度 | 1.5±0.1 g/cm3 | 沸点 | 576.7±50.0 °C at 760 mmHg | |
| 分子式 | C16H12O6 | 熔点 | 256-258ºC | |
| MSDS | 中文版 美版 | 闪点 | 220.3±23.6 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Antiviral effect of methylated flavonol isorhamnetin against influenza.
PLoS ONE 10(3) , e0121610, (2015) Influenza is an infectious respiratory disease with frequent seasonal epidemics that causes a high rate of mortality and morbidity in humans, poultry, and animals. Influenza is a serious economic concern due to the costly countermeasures it necessitates. In t... |
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Differential metabolomic analysis of the potential antiproliferative mechanism of olive leaf extract on the JIMT-1 breast cancer cell line.
J. Pharm. Biomed. Anal. 105 , 156-62, (2015) A new differential metabolomic approach has been developed to identify the phenolic cellular metabolites derived from breast cancer cells treated with a supercritical fluid extracted (SFE) olive leaf extract. The SFE extract was previously shown to have signi... |
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Flavonoids are inhibitors of human organic anion transporter 1 (OAT1)-mediated transport.
Drug Metab. Dispos. 42(9) , 1357-66, (2014) Organic anion transporter 1 (OAT1) has been reported to be involved in the nephrotoxicity of many anionic xenobiotics. As current clinically used OAT1 inhibitors are often associated with safety issues, identifying potent OAT1 inhibitors with little toxicity ... |
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Effect of diosmetin on airway remodeling in a murine model of chronic asthma.
Acta Biochim. Biophys. Sin. (Shanghai) 47 , 604-11, (2015) Bronchial asthma, one of the most common allergic diseases, is characterized by airway hyperresponsiveness (AHR), inflammation, and remodeling. The anti-oxidant flavone aglycone diosmetin ameliorates the inflammation in pancreatitis, but little is known about... |
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Simultaneous quantification of 25 active constituents in the total flavonoids extract from Herba Desmodii Styracifolii by high-performance liquid chromatography with electrospray ionization tandem mass spectrometry.
J. Sep. Sci. 38(7) , 1156-63, (2015) A sensitive and selective high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry method has been developed and validated for the simultaneous determination of 25 active constituents, including 21 flavonoids and fo... |
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Electrospinning of diosmin from aqueous solutions for improved dissolution and oral absorption.
Int. J. Pharm. 473(1-2) , 407-13, (2014) A nanofibrous membrane carrier for nearly water insoluble drug diosmin was formulated. The aim of this study was to evaluate the drug release and dissolution properties in an aqueous buffer of pH 7.8, and to compare the suitability of the drug carrier with th... |
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[Chemical constituents contained in seeds of Notopterygium franchetii].
Zhongguo Zhong Yao Za Zhi 37(7) , 941-5, (2012) To study the chemical constituents from the seeds of Notopterygium franchetii.Ethanol extracts of seeds N. franchetii were separated and purified by such methods as normal and reversed phase column chromatographies and thin-layer chromatography and structural... |
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Flavonoids for controlling starch digestion: structural requirements for inhibiting human alpha-amylase.
J. Med. Chem. 51 , 3555-61, (2008) In this study we investigated the structural requirements for inhibition of human salivary alpha-amylase by flavonoids. Four flavonols and three flavones, out of the 19 flavonoids tested, exhibited IC50 values less than 100 microM against human salivary alpha... |
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Prediction of intestinal absorption and metabolism of pharmacologically active flavones and flavanones.
Bioorg. Med. Chem. 16 , 4009-18, (2008) Three glycosilated flavonoids (diosmin, hesperidin and naringin) and respective aglycones were characterized in terms of their apparent ionisation constants and bidirectional permeability using the cellular model Caco-2 as well as the artificial membrane mode... |
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7-Hydroxy-benzopyran-4-one derivatives: a novel pharmacophore of peroxisome proliferator-activated receptor alpha and -gamma (PPARalpha and gamma) dual agonists.
J. Med. Chem. 52 , 6835-50, (2009) Design, synthesis, and in vitro bioevaluation of a new class of potential dual PPARalpha and gamma agonists discovered through a structure-driven design paradigm are described. The 7-hydroxy-benzopyran-4-one moiety (includes flavones, flavanones, and isoflavo... |