甲基莲心碱
甲基莲心碱结构式
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常用名 | 甲基莲心碱 | 英文名 | Neferine |
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| CAS号 | 2292-16-2 | 分子量 | 624.766 | |
| 密度 | 1.2±0.1 g/cm3 | 沸点 | 710.9±60.0 °C at 760 mmHg | |
| 分子式 | C38H44N2O6 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 383.8±32.9 °C |
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In vitro opioid receptor affinity and in vivo behavioral studies of Nelumbo nucifera flower.
J. Ethnopharmacol. 174 , 57-65, (2015) Nelumbo nucifera Geartn., known as sacred lotus, has been used traditionally in South East Asia as a traditional medicine for various CNS disorders including stress, fever, depression, insomnia, and cognitive conditions.To investigate the in vitro cannabinoid... |
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Anti-amnesic activity of neferine with antioxidant and anti-inflammatory capacities, as well as inhibition of ChEs and BACE1.
Life Sci. 87(13-14) , 420-30, (2010) the multifunctional potential of neferine derived from the embryo of Nelumbo nucifera seeds for the age-related neurodegenerative disorders, in vivo anti-amnesic activities and in vitro cholinesterases (ChEs)- and β-site APP cleaving enzyme 1 (BACE1)-inhibito... |
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Blockade of HERG K+ channel by isoquinoline alkaloid neferine in the stable transfected HEK293 cells.
Naunyn Schmiedebergs Arch. Pharmacol. 380(2) , 143-51, (2009) We studied the effects of isoquinoline alkaloid neferine (Nef) extracted from the seed embryo of Nelumbo nucifera Gaertn on Human ether-à-go-go-related gene (HERG) channels stably expressed in human embryonic kidney (HEK293) cells using whole-cell patch clamp... |
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Synthesis and pharmacological activity of alkaloids from embryo of lotus, Nelumbo nucifera.
Chem. Pharm. Bull. 61(1) , 59-68, (2013) Bisbenzylisoquinoline alkaloid, nelumboferine which was recently isolated from the embryo of Nelumbo nucifera, and stereoisomers of neferine, which is a major alkaloid of the embryo of N. nucifera, were stereoselectively synthesized. Pharmacological activity ... |
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Effect of neferine on liver ischemia-reperfusion injury in rats.
Transplant. Proc. 43(7) , 2536-9, (2011) Liver ischemia/reperfusion leads to the formation of reactive oxygen species (ROS) that cause liver injury, a critical clinical problem during liver surgery and transplantation. The aim of the present study was to investigate the hepatoprotective and antioxid... |
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Effects of neferine on CCL5 and CCR5 expression in SCG of type 2 diabetic rats.
Brain Res. Bull. 90 , 79-87, (2013) Chemokines and their receptors have the key role in inflammatory responses. The phenomenon of low grade inflammation is associated with the development of type 2 diabetes. Postprandial hyperglycemia increases the systemic inflammatory responses, which promote... |
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Neferine increases STI571 chemosensitivity via inhibition of P-gp expression in STI571-resistant K562 cells.
Leuk. Lymphoma 52(4) , 694-700, (2011) We investigated the effects of neferine (Nef) on STI571 sensitivity and the possible mechanism in STI571-resistant K562/G01 cells. We observed cell proliferation by the modified MTT (methyl thiazolyl tetrazolium) assay. We determined the intracellular concent... |
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Effects of neferine on the pharmacokinetics of amiodarone in rats.
Biomed. Chromatogr. 25(8) , 858-66, (2011) Amiodarone, an iodinated benzofuran derivative with predominantly class III anti-arrhythmic effects, is used to treat supraventricular and ventricular arrhythmias. The purpose of this study was to assess the potential of neferine, an effective anti-pulmonary ... |
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Simultaneous determination of liensinine, isoliensinine and neferine from seed embryo of Nelumbo nucifera Gaertn. in rat plasma by a rapid HPLC method and its application to a pharmacokinetic study.
Arzneimittelforschung 61(6) , 347-52, (2011) A rapid and specific HPLC method has been developed and validated for the simultaneous determination of liensinine (CAS 2586-96-1), isoliensinine (CAS 6817-41-0) and neferine (CAS 2292-16-2) in rat plasma. The sample was prepared by a liquid-liquid extraction... |
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Neferine inhibits the upregulation of CCL5 and CCR5 in vascular endothelial cells during chronic high glucose treatment.
Inflammation 36(2) , 300-8, (2013) We investigated whether the expressions of CCL5 and CCR5 participate in dysfunctional changes in human umbilical vein endothelial cells (HUVECs) induced by chronic high glucose treatment and examined whether neferine exerts its therapeutic effects by blocking... |