Chemical & Pharmaceutical Bulletin 2013-01-01

Synthesis and pharmacological activity of alkaloids from embryo of lotus, Nelumbo nucifera.

Katsumi Nishimura, Shinji Horii, Takao Tanahashi, Yumi Sugimoto, Jun Yamada

文献索引：Chem. Pharm. Bull. 61(1) , 59-68, (2013)

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摘要

Bisbenzylisoquinoline alkaloid, nelumboferine which was recently isolated from the embryo of Nelumbo nucifera, and stereoisomers of neferine, which is a major alkaloid of the embryo of N. nucifera, were stereoselectively synthesized. Pharmacological activity of nelumboferine, stereoisomers of neferine, liensinine, isoliensinine, and O-methylneferine were evaluated.