奥卡西平
奥卡西平结构式
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常用名 | 奥卡西平 | 英文名 | Oxcarbazepine |
|---|---|---|---|---|
| CAS号 | 28721-07-5 | 分子量 | 252.268 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 457.2±55.0 °C at 760 mmHg | |
| 分子式 | C15H12N2O2 | 熔点 | 215-216°C | |
| MSDS | 中文版 美版 | 闪点 | 230.3±31.5 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Functionalized nanocarrier combined seizure-specific vector with P-glycoprotein modulation property for antiepileptic drug delivery.
Biomaterials 74 , 64-76, (2015) Despite optimal therapeutic regimen with currently available antiepileptic drugs (AEDs), approximately a third of epilepsy patients remain drug refractory. Region-specific overexpression of multidrug efflux transporters at the blood-brain barrier, such as P-g... |
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Development of a SPE-HPLC-MS/MS method for the determination of most prescribed pharmaceuticals and related metabolites in urban sewage samples.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 990 , 23-30, (2015) Based on regional prescription data several pharmaceuticals with variable amounts of prescription and corresponding metabolites were selected and analyzed in influent and effluent samples of the sewage treatment plant (STP) in Dresden, Germany. Pharmaceutical... |
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Enhanced brain delivery of lamotrigine with Pluronic(®) P123-based nanocarrier.
Int. J. Nanomedicine 9 , 3923-35, (2014) P-glycoprotein (P-gp) mediated drug efflux across the blood-brain barrier (BBB) is an important mechanism underlying poor brain penetration of certain antiepileptic drugs (AEDs). Nanomaterials, as drug carriers, can overcome P-gp activity and improve the targ... |
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Carbamazepine-Induced Liver Injury Requires CYP3A-Mediated Metabolism and Glutathione Depletion in Rats.
Drug Metab. Dispos. 43 , 958-68, (2015) Carbamazepine (CBZ) is widely used as an antiepileptic agent and causes rare but severe liver injury in humans. It has been generally recognized that reactive metabolites formed via the metabolic activation reaction contribute to the onset of liver injuries b... |
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Eslicarbazepine and the enhancement of slow inactivation of voltage-gated sodium channels: a comparison with carbamazepine, oxcarbazepine and lacosamide.
Neuropharmacology 89 , 122-35, (2014) This study aimed at evaluating the effects of eslicarbazepine, carbamazepine (CBZ), oxcarbazepine (OXC) and lacosamide (LCM) on the fast and slow inactivated states of voltage-gated sodium channels (VGSC). The anti-epileptiform activity was evaluated in mouse... |
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Evaluation of the matrix effect of different sample matrices for 33 pharmaceuticals by post-column infusion.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 1000 , 84-94, (2015) Matrix effects that occur during quantitative measurement by liquid chromatography mass spectrometry specifically when using electrospray ionization are a widely recognized phenomenon. Sample matrix compounds affect the ionization process of the target analyt... |
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Oxcarbazepine versus phenytoin monotherapy for epilepsy.
Cochrane Database Syst. Rev. 5 , CD003615, (2013) This is an updated version of the original Cochrane review published in The Cochrane Library 2006, Issue 2.Worldwide, phenytoin is a commonly used antiepileptic drug. For the newer drugs such as oxcarbazepine, it is important to know how they compare with sta... |
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Carbamazepine and oxcarbazepine, but not eslicarbazepine, enhance excitatory synaptic transmission onto hippocampal CA1 pyramidal cells through an antagonist action at adenosine A1 receptors.
Neuropharmacology 93 , 103-15, (2015) This study assessed the anticonvulsant and seizure generation effects of carbamazepine (CBZ), oxcarbazepine (OXC) and eslicarbazepine (S-Lic) in wild-type mice. Electrophysiological recordings were made to discriminate potential cellular and synaptic mechanis... |
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The novel anticonvulsant BIA 2-093 inhibits transmitter release during opening of voltage-gated sodium channels: a comparison with carbamazepine and oxcarbazepine.
Neurochem. Int. 40 , 435-440, (2002) (S)-(-)-10-acetoxy-10,11-dihydro-5H-dibenz/b,f/azepine-5-carboxamide (BIA 2-093) is endowed with high anticonvulsant activity and shares with carbamazepine (CBZ) and oxcarbazepine (OXC) the capability to inhibit voltage-gated sodium channels (VGSC). The prese... |
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Depression and anxiety in women with epilepsy during pregnancy and after delivery: a prospective population-based cohort study on frequency, risk factors, medication, and prognosis.
Epilepsia 56(1) , 28-39, (2015) To assess incidence, prevalence, risk factors, and prognosis of peripartum depression and anxiety in a prospective study of women with epilepsy.Pregnancies in women with epilepsy (n=706) were compared to pregnancies in all women without epilepsy (n=106,511) i... |