阿莫沙平
阿莫沙平结构式
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常用名 | 阿莫沙平 | 英文名 | Amoxapine |
|---|---|---|---|---|
| CAS号 | 14028-44-5 | 分子量 | 313.78100 | |
| 密度 | 1.37g/cm3 | 沸点 | 469.9ºC at 760mmHg | |
| 分子式 | C17H16ClN3O | 熔点 | 175-1760C | |
| MSDS | 中文版 美版 | 闪点 | 238ºC | |
| 符号 |
GHS07 |
信号词 | Warning |
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Inhibition of G protein-activated inwardly rectifying K+ channels by different classes of antidepressants.
PLoS ONE 6(12) , e28208, (2011) Various antidepressants are commonly used for the treatment of depression and several other neuropsychiatric disorders. In addition to their primary effects on serotonergic or noradrenergic neurotransmitter systems, antidepressants have been shown to interact... |
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Investigation of the disposition of loxapine, amoxapine and their hydroxylated metabolites in different brain regions, CSF and plasma of rat by LC–MS/MS
J. Pharm. Biomed. Anal. 58 , 83-93, (2012) Loxapine represents an interesting example of old “new” drug and is recently drawing attention for its novel inhalation formulation for the treatment of both psychiatric and non-psychiatric disorders. It is extensively metabolized to several active metabolite... |
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Validation of HPLC-MS/MS methods for analysis of loxapine, amoxapine, 7-OH-loxapine, 8-OH-loxapine and loxapine N-oxide in human plasma.
Bioanalysis 2(12) , 1989-2000, (2010) Two ESI-LC-MS/MS methods were validated for the quantitative analysis of loxapine, amoxapine, 7-OH-loxapine, 8-OH-loxapine and loxapine N-oxide in human K(2)EDTA plasma. Cation-exchange solid-phase extraction (SPE) was used to extract loxapine, amoxapine and ... |
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Potential repurposing of known drugs as potent bacterial β-glucuronidase inhibitors.
J. Biomol. Screen. 17(7) , 957-65, (2012) The active metabolite of the chemotherapeutic irinotecan, SN-38, is detoxified through glucuronidation and then excreted into the gastrointestinal tract. Intestinal bacteria convert the glucuronidated metabolite back to the toxic SN-38 using β-glucuronidase (... |
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Amoxapine-associated acute respiratory distress.
Respirology 13(1) , 149-51, (2008) A 37-year-old woman was admitted to our hospital because of acute respiratory distress. Two weeks previously, amoxapine (75 mg/day) had been administered for the first time. Ten days later she developed a high fever, severe hypoxaemia and pulmonary infiltrate... |
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Pharmacological properties of glycine uptake in the developing rat retina.
Neurochem. Int. 49(4) , 342-6, (2006) A pharmacological characterization of glycine transport was performed in the rat retina at different postnatal ages. The uptake of 3H-glycine increased during the first 2 weeks of postnatal age, reaching maximum values at 12 days; then it decreased sharply to... |
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DPP-IV inhibitor may affect spermatogenesis.
Diabetes Res. Clin. Pract. 93(2) , e74-5, (2011) A 39-year-old physician was diagnosed retrograde ejaculation due to diabetes and treated with amoxapine. This treatment was effective; he could ejaculate. He began receiving DPP-IV inhibitor (Sitagliptin 50 mg, daily), in lieu of insulin injection. Unusual ef... |
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Functional expression of the glycine transporter 1 on bullfrog retinal cones.
Neuroreport 19(17) , 1667-71, (2008) Using patch clamp techniques, we characterized glycine-induced currents from cones in bullfrog retinal slices. Application of glycine to cone terminals induced an inward current, which was in part suppressed by strychnine. The remaining strychnine-resistant c... |
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Refractory hypotension during general anaesthesia caused by the long-term use of amoxapine.
Anaesth. Intensive Care 38(5) , 965-6, (2010)
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Syndrome of inappropriate secretion of anti-diuretic hormone in an elderly depressive patient receiving paroxetine: a case report.
Int. J. Geriatr. Psychiatry 25(4) , 433-4, (2010)
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