Anthopleurin-A
Anthopleurin-A结构式
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常用名 | Anthopleurin-A | 英文名 | Anthopleurin-A |
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| CAS号 | 60880-63-9 | 分子量 | 5131.72 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C220H326N64O67S6 | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | N/A |
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Chemical modification of cationic groups in the polypeptide cardiac stimulant anthopleurin-A.
Toxicon 33(2) , 187-99, (1995) Chemical modification studies have been carried out on the sea anemone polypeptide anthopleurin-A in order to clarify the role of Arg-14 in its cardiac stimulatory activity. Reaction with 1,2-cyclohexanedione at 37 degrees C produced a range of protein produc... |
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Spatial dispersion of repolarization is a key factor in the arrhythmogenicity of long QT syndrome.
J. Cardiovasc. Electrophysiol. 15(3) , 323-31, (2004) The occurrence of significant spatial dispersion of repolarization in vivo as it relates to the mechanism of arrhythmia formation in the long QT syndrome (LQTS) continues to be questioned.We investigated a guinea pig model of LQT3 using anthopleurin-A (AP-A) ... |
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Three-dimensional structure in solution of the polypeptide cardiac stimulant anthopleurin-A.
Biochemistry 34(11) , 3782-94, (1995) The three-dimensional structure in aqueous solution of the 49-residue polypeptide anthopleurin-A (AP-A), from the sea anemone Anthopleura xanthogrammica, has been determined from 1H NMR data. A restraint set consisting of 411 interproton distance restraints i... |
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Synthesis of the cardiac inotropic polypeptide anthopleurin-A.
Int. J. Pept. Protein Res. 43(5) , 463-70, (1994) The sea anemone polypeptide anthopleurin-A (AP-A) at nanomolar concentrations enhances myocardial contractility without affecting automaticity. It has a therapeutic index higher than that of the digitalis glycosides, and may serve as a molecular model for des... |
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The outermost lysine in the S4 of domain III contributes little to the gating charge in sodium channels.
Biophys. J. 82(6) , 3048-55, (2002) We investigated the contribution the four outermost basic residues (K1, R2, R3, R4) in segment 4 of domain III in the human cardiac Na channel (hH1a, Na(V)1.5) to the total gating charge (Q(max)). Each of the four basic residues were mutated individually to a... |
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Enhancement of closed-state inactivation in long QT syndrome sodium channel mutation DeltaKPQ.
Am. J. Physiol. Heart Circ. Physiol. 283(3) , H966-75, (2002) DeltaKPQ, a three amino acid [lysine (K), proline (P), glutamine (Q)] deletion mutation of the human cardiac Na channel (hH1), which is one cause of long QT syndrome (LQT3), has impaired inactivation resulting in a late sodium current. To better understand in... |
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Multiple conformations of the sea anemone polypeptide anthopleurin-A in solution.
Protein Sci. 3(7) , 1121-4, (1994) Anthopleurin-A (AP-A) is a member of a family of sea anemone-derived polypeptides that interact with sodium channels in a voltage-dependent manner, producing a positive inotropic effect on the mammalian heart. There has been considerable interest in this mole... |
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Arrhythmogenesis of T wave alternans associated with surface QRS complex alternans and the role of ventricular prematurity: observations from a canine model of LQT3 syndrome.
J. Cardiovasc. Electrophysiol. 13(6) , 599-604, (2002) T wave alternans (TWA) is characterized by cycle-to-cycle changes in the QT interval and/or T wave morphology. It is believed to amplify the underlying dispersion of ventricular repolarization. The aim of this study was to examine the mechanisms and arrhythmo... |
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Effect of sea anemone toxin anthopleurin-Q on sodium current in guinea pig ventricular myocytes.
Acta Pharmacol. Sin. 22(12) , 1107-12, (2001) To investigate the effects of a sea anemone toxin anthopleurin-Q (AP-Q) isolated from Anthopleura xanthogrammica on sodium current (INa) in isolated guinea pig ventricular myocytes.Single myocytes were dissociated by enzymatic dissociation method. INa was rec... |
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Cycle length-associated modulation of the regional dispersion of ventricular repolarization in a canine model of long QT syndrome.
Pacing Clin. Electrophysiol. 24(8 Pt 1) , 1247-57, (2001) Previous tridimensional activation mapping showed that the development of functional conduction block at the onset of torsades de pointes was regionally heterogeneous; conduction block was frequently observed in the LV and the interventricular septum (IVS) bu... |