Restrictocin
Restrictocin结构式
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常用名 | Restrictocin | 英文名 | Restrictocin |
|---|---|---|---|---|
| CAS号 | 1406-72-0 | 分子量 | 355.474 | |
| 密度 | 1.1±0.1 g/cm3 | 沸点 | 577.7±50.0 °C at 760 mmHg | |
| 分子式 | C21H29N3O2 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 303.2±30.1 °C | |
| 符号 |
GHS07, GHS08 |
信号词 | Danger |
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The ribotoxin restrictocin recognizes its RNA substrate by selective engagement of active site residues.
Biochemistry 50(14) , 3004-13, (2011) Restrictocin and related fungal endoribonucleases from the α-sarcin family site-specifically cleave the sarcin/ricin loop (SRL) on the ribosome to inhibit translation and ultimately trigger cell death. Previous studies showed that the SRL folds into a bulged-... |
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Role of individual cysteine residues and disulfide bonds in the structure and function of Aspergillus ribonucleolytic toxin restrictocin.
Biochemistry 38(31) , 10052-8, (1999) Restrictocin, produced by the fungus Aspergillus restrictus, belongs to the group of ribonucleolytic toxins called ribotoxins. It specifically cleaves a single phosphodiester bond in a conserved stem and loop structure in the 28S rRNA of large ribosomal subun... |
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Mechanism of specific target recognition and RNA hydrolysis by ribonucleolytic toxin restrictocin.
Biochemistry 40(31) , 9115-24, (2001) Restrictocin, a member of the fungal ribotoxin family, specifically cleaves a single phosphodiester bond in the 28S rRNA and potently inhibits eukaryotic protein synthesis. Residues Tyr47, His49, Glu95, Phe96, Pro97, Arg120, and His136 have been predicted to ... |
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Electrostatic interactions guide the active site face of a structure-specific ribonuclease to its RNA substrate.
Biochemistry 47(34) , 8912-8, (2008) Restrictocin, a member of the alpha-sarcin family of site-specific endoribonucleases, uses electrostatic interactions to bind to the ribosome and to RNA oligonucleotides, including the minimal specific substrate, the sarcin/ricin loop (SRL) of 23S-28S rRNA. R... |
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[Antibody detection in patients with invasive aspergillosis].
Mycoses 47 Suppl 1 , 55-9, (2004) The clinical significance of Aspergillus antibody assays for the diagnosis of invasive aspergillosis (IA) is unclear. In two studies, three different antibody assays were evaluated with patients suffering from proven IA: (i) a commercial haemagglutination tes... |
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Expression of an epitopic region of AspfI, an allergen/antigen/cytotoxin of Aspergillus fumigatus.
Immunol. Lett. 70(3) , 151-5, (1999) The gene for an 18 kD allergen/cytotoxin of Aspergillus fumigatus was cloned in pUC-19 vector and expressed in Escherichia coli JM109. Digestion of this gene with AluI resulted in four fragments of 216bp, 120bp, 39bp and 21bp. These fragments were cloned in t... |
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Role of cis prolines 112 and 126 in the functional activity of ribonucleolytic toxin restrictocin.
Biochem. Biophys. Res. Commun. 295(4) , 812-7, (2002) Restrictocin is a 149 amino acid ribonucleolytic toxin produced by the fungus Aspergillus, which specifically cleaves a single phosphodiester bond within 28S rRNA resulting in a potent inhibition of protein synthesis in eukaryotic cells. Restrictocin has 12 p... |
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Modification of an expression vector for efficient recombinant production and purification of mitogillin of Aspergillus fumigatus expressed in Escherichia coli.
Protein Expr. Purif. 76(1) , 90-6, (2011) The diagnostic potential of secretory proteins of Aspergillus fumigatus is limited by their availability in pure form. We have constructed a vector (pGES-PH-1) to express genes encoding secretory proteins of A. fumigatus as fusion proteins with glutathione S-... |
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The effect of fungal ribosome inactivating proteins upon feeding choice in C. freemani, and indications of a mutualistic relationship with A. restrictus. Environmental mycology.
Mycopathologia 152(3) , 155-8, (2001) Carpophilus freemani beetles' feeding on the fungus Aspergillus nidulans was substantially inhibited when A. nidulans was transformed and induced to secrete the ribosome inactivating protein, restrictocin (genetic source: Aspergillus restrictus). No inhibitio... |
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Involvement of loops L2 and L4 of ribonucleolytic toxin restrictocin in its functional activity.
Protein Pept. Lett. 14(2) , 125-9, (2007) Restrictocin, a member of the fungal ribotoxin family, specifically cleaves a single phosphodiester bond in the 28S rRNA and potently inhibits eukaryotic protein synthesis. The long loops in restrictocin molecule have been shown structurally to be involved in... |