PACAP(1-38),人,绵羊,大鼠
PACAP(1-38),人,绵羊,大鼠结构式
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常用名 | PACAP(1-38),人,绵羊,大鼠 | 英文名 | PACAP(6-38), human, ovine, rat |
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| CAS号 | 137061-48-4 | 分子量 | 4534.26 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C203H331N63O53S | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | N/A |
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Epac2 contributes to PACAP-induced astrocytic differentiation through calcium ion influx in neural precursor cells.
BMB Rep. 49 , 128-33, (2016) Astrocytes play a critical role in normal brain functions and maintaining the brain microenvironment, and defects in astrocytogenesis during neurodevelopment could give rise to severe mental illness and psychiatric disorders. During neuro-embryogenesis, astro... |
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The role of VIP/PACAP receptor subtypes in spinal somatosensory processing in rats with an experimental peripheral mononeuropathy.
Neuropharmacology 38 , 167-180, (1999) Peripheral nerve damage often results in the development of chronic pain states, resistant to classical analgesics. Since vasoactive intestinal polypeptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) are up-regulated in dorsal root ga... |
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Pituitary adenylate cyclase-activating peptide 38 a potent endogenously produced dilator of human airways.
Eur. Respir. J. 15 , 243-247, (2000) Pituitary adenylate cyclase-activating peptide (PACAP) 38 displays several biological activities relevant to obstructive airway disease. In this study, the occurrence of PACAP 38 in human small bronchi and corresponding pulmonary arteries was analysed immunoc... |
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PACAP-(1-38) as neurotransmitter in the porcine adrenal glands.
Am. J. Physiol. Endocrinol. Metab. 279 , E1413-E1425, (2000) The concentration of pituitary adenylyl cyclase-activating polypeptide [PACAP-(1-38)] in porcine adrenal glands amounted to 14 +/- 3 pmol/g tissue. PACAP immunoreactive (PACAP-IR) fibers innervated adrenal chromaffin cells (often co-localized with choline ace... |
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Pituitary adenylate cyclase activating polypeptide is an extraordinarily potent intra-pancreatic regulator of insulin secretion from islet beta-cells.
J. Biol. Chem. 269 , 1290-1293, (1994) Insulin secretion from pancreatic islets is controlled by peptides as well as by nutrients. We report here a novel, extraordinarily potent peptidergic regulation of insulin secretion. A 27-residue form of pituitary adenylate cyclase activating polypeptide (PA... |
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Pituitary adenylate cyclase-activating polypeptide (PACAP) 38 and PACAP27 activate common and distinct intracellular signaling pathways to stimulate growth hormone secretion from porcine somatotropes.
Endocrinology 139 , 5116-5124, (1998) We have recently shown that the two bioactive forms of pituitary adenylate cyclase-activating polypeptide, PACAP38 and PACAP27, stimulate GH release and GH messenger RNA (mRNA) accumulation in cultured porcine pituitary cells. However, dose- and time-related ... |
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Domains determining agonist selectivity in chimaeric VIP2 (VPAC2)/PACAP (PAC1) receptors.
Br. J. Pharmacol. 128 , 934-940, (1999) 1 The VPAC2 and PAC1 receptors are closely related members of the Group II G protein-coupled receptor family. At the VPAC2 receptor, VIP is equipotent to PACAP-38 in stimulating cyclic AMP production, whereas at the PAC1 receptor PACAP-38 is many fold more po... |