神经节苷酯GM<sub>2</sub>
神经节苷酯GM<sub>2</sub>结构式
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常用名 | 神经节苷酯GM<sub>2</sub> | 英文名 | Ganglioside GM2 Asialo Mixture |
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| CAS号 | 35960-33-9 | 分子量 | 1093.4 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C56H104N2O18 | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | N/A |
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Asialo GM-2 developed on the fatty streak of atherosclerotic aorta detected by a novel monoclonal antibody (ASH1a/256C).
Ann. N. Y. Acad. Sci. 748 , 277-81; discussion 281-2, (1995)
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Catabolism of asialo-GM2 in man and mouse. Specificity of human/mouse chimeric GM2 activator proteins.
J. Biol. Chem. 274(40) , 28612-8, (1999) Tay-Sachs disease is an inborn lysosomal disease characterized by excessive cerebral accumulation of GM2. The catabolism of GM2 to GM3 in man requires beta-hexosaminidase A (HexA) and a protein cofactor, the GM2 activator. Thus, Tay-Sachs disease can be cause... |
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Optimal conditions to radiolabel (3H or 14C) aminosugar-containing glycosphingolipids by de-N-acetylation and re-N-acetylation.
Biochim. Biophys. Acta 1244(2-3) , 418-22, (1995) The optimal conditions were examined for selective re-N-acetylation with 14C or 3H.acetic anhydride of de-N-acetylated aminosugar-containing glycosphingolipids. Re-N-acetylation, which is nearly quantitative within 10 minutes in methanol, occurs selectively u... |
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Soluble fibronectin interaction with cell surface and extracellular matrix is mediated by carbohydrate-to-carbohydrate interaction.
Arch. Biochem. Biophys. 374(1) , 93-9, (2000) Cell adhesion and spreading on solid phase fibronectin (FN), coated on plate or presented in extracellular matrix, are mediated by integrin receptors alpha5beta1, alpha4beta1, etc., although binding of "soluble-form FN" to cell surface varies extensively depe... |
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Enzymatic sulfation of gangliotriaosylceramide in human renal cancer cells.
J. Biochem. 117(5) , 987-92, (1995) Biosynthesis of sulfoglycolipid is markedly increased in a human renal cancer cell line, SMKT-R3. We investigated the sulfotransferase catalyzing the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to gangliotriaosylceramide (Gg3Cer) in ... |
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Oligosaccharide receptor mimics inhibit Legionella pneumophila attachment to human respiratory epithelial cells.
Microb. Pathog. 36(2) , 83-92, (2004) Legionnaire's disease is caused by the intracellular pathogen Legionella pneumophila, presenting as an acute pneumonia. Attachment is the key step during infection, often relying on an interaction between host cell oligosaccharides and bacterial adhesins. Inh... |
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Cloned beta 1,4N-acetylgalactosaminyltransferase: subcellular localization and formation of disulfide bonded species.
Glycoconj. J. 13(2) , 213-23, (1996) Cloned human beta 1,4N-acetylgalactosaminyltransferase (GalNAcT) catalyzes the synthesis of the glycosphingolipids GM2, GD2, and gangliotriosylceramide. To determine the subcellular location of this enzyme and whether it exists in intermolecular disulfide bon... |
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Structural characterization of a novel mono-sulfated gangliotriaosylceramide containing a 3-O-sulfated N-acetylgalactosamine from rat kidney.
Glycoconj. J. 13(2) , 285-93, (1996) A novel mono-sulfated glycosphingolipid based on the gangliotriaose core structure was isolated from rat kidney. The isolation procedure involved extraction of lipids with chloroform/methanol, mild alkaline methanolysis, column chromatographies with anion exc... |
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Recombinant GM2-activator protein stimulates in vivo degradation of GA2 in GM2 gangliosidosis AB variant fibroblasts but exhibits no detectable binding of GA2 in an in vitro assay.
Neurochem. Res. 24(2) , 295-300, (1999) The interaction between glycosphingolipids and recombinant human GM2-activator was studied in a microwell binding assay. A-series gangliosides like GM3, GM2 and GM1 were strongly bound by the recombinant human GM2 activator. A weak binding was observed to GD1... |
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Biosynthesis of the so-called "a" and "asialo" pathway glycosphingolipids is differentially regulated in murine myelogenous leukemia NFS60 cells.
Biochem. Biophys. Res. Commun. 217(3) , 733-40, (1995) Regulation of "a" and "asialo" series ganglioside biosynthesis was analyzed. COS-1 cells expressing only GD1a showed high synthetic activities of GM3, GM2, GM1a, and GD1a, but little activity for GA2 synthesis. However, IL-3-dependent murine NFS60-I7, which h... |