Tacrine hydrochloride hydrate
Tacrine hydrochloride hydrate结构式
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常用名 | Tacrine hydrochloride hydrate | 英文名 | Tacrine hydrochloride hydrate |
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| CAS号 | 206658-92-6 | 分子量 | 252.740 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C13H17ClN2O | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | N/A | |
| 符号 |
GHS06, GHS08 |
信号词 | Danger |
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Synthesis, biological activity, and biopharmaceutical characterization of tacrine dimers as acetylcholinesterase inhibitors.
Int. J. Pharm. 477(1-2) , 442-53, (2014) Tacrine (THA), as the first approved acetylcholinesterase (AChE) inhibitors for the treatment of Alzheimer's disease (AD), has been extensively investigated in last seven decades. After dimerization of THA via a 7-carbon alkyl spacer, bis(7)-tacrine (B7T) sho... |
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Influence of electronic and formulation variables on transdermal iontophoresis of tacrine hydrochloride.
Pharm. Dev. Technol. 20 , 442-57, (2015) Freshly excised rat skin and side-by-side permeation cells were used to study the effect of electronic and formulation variables on transdermal iontophoretic delivery of tacrine. Current strength at 0.1-0.3 mA was observed to be the driving force resulting in... |
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Tacrine sinusoidal uptake and biliary excretion in sandwich-cultured primary rat hepatocytes.
J. Pharm. Pharm. Sci. 17(3) , 427-38, (2014) PURPOSE. The knowledge of hepatic disposition kinetics of tacrine, a first cholinesterase inhibitor was approved by FDA for the treatment of Alzheimer's disease (AD), would help to understand its hepatotoxicity, its therapeutic effect, and improve the managem... |
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Multifunctional liposomes for nasal delivery of the anti-Alzheimer drug tacrine hydrochloride.
J. Liposome Res. 24(4) , 323-35, (2014) The purpose of this study was the development of multifunctional liposomes for nasal administration of tacrine hydrochloride. Liposomes were prepared using traditional excipients (cholesterol and phosphatidylcholine), partly enriched with α-tocopherol and/or ... |
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Synthesis and characterization of 1H-phenanthro[9,10-d]imidazole derivatives as multifunctional agents for treatment of Alzheimer's disease.
Biochim. Biophys. Acta 1840(9) , 2886-903, (2014) Alzheimer's disease (AD) is a progressive neurodegenerative brain disorder that is characterized by dementia, cognitive impairment, and memory loss. Diverse factors are related to the development of AD, such as increased level of β-amyloid (Aβ), acetylcholine... |
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Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase.
Proc. Natl. Acad. Sci. U. S. A. 90 , 9031, (1993) Binding sites of Torpedo acetylcholinesterase (EC 3.1.1.7) for quaternary ligands were investigated by x-ray crystallography and photoaffinity labeling. Crystal structures of complexes with ligands were determined at 2.8-A resolution. In a complex with edroph... |
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Effects of cabergoline and rotigotine on tacrine-induced tremulous jaw movements in rats.
Pharmacol. Biochem. Behav. 126 , 103-8, (2014) We examined the effects of two dopamine agonists, cabergoline and rotigotine, on tacrine-induced tremor and c-Fos expression in rats.Rats received intraperitoneal injection of cabergoline (0.5, 1.0, or 5.0mg/kg), rotigotine (1.0, 2.5, or 10.0mg/kg), or vehicl... |
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Flow-through enzyme immobilized amperometric detector for the rapid screening of acetylcholinesterase inhibitors by flow injection analysis.
J. Pharm. Biomed. Anal. 102 , 267-75, (2015) A commercially available thin-layer flow-through amperometric detector, with the sensing block customized in an original design, was applied to the screening of drug compounds known as acetylcholinesterase (AChE) inhibitors. AChE from electric eel was covalen... |