阿糖胞苷
阿糖胞苷结构式
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常用名 | 阿糖胞苷 | 英文名 | Cytarabine |
|---|---|---|---|---|
| CAS号 | 147-94-4 | 分子量 | 243.217 | |
| 密度 | 1.9±0.1 g/cm3 | 沸点 | 529.7±60.0 °C at 760 mmHg | |
| 分子式 | C9H13N3O5 | 熔点 | 214 °C | |
| MSDS | 中文版 美版 | 闪点 | 274.1±32.9 °C | |
| 符号 |
GHS07, GHS08 |
信号词 | Warning |
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Retinoic acid synergizes ATO-mediated cytotoxicity by precluding Nrf2 activity in AML cells.
Br. J. Cancer 111(5) , 874-82, (2014) Standard therapy for acute promyelocytic leukaemia (APL) includes retinoic acid (all-trans retinoic acid (ATRA)), which promotes differentiation of promyelocytic blasts. Although co-administration of arsenic trioxide (ATO) with ATRA has emerged as an effectiv... |
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African swine fever virus ORF P1192R codes for a functional type II DNA topoisomerase.
Virology 474 , 82-93, (2014) Topoisomerases modulate the topological state of DNA during processes, such as replication and transcription, that cause overwinding and/or underwinding of the DNA. African swine fever virus (ASFV) is a nucleo-cytoplasmic double-stranded DNA virus shown to co... |
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PMP22 is critical for actin-mediated cellular functions and for establishing lipid rafts.
J. Neurosci. 34(48) , 16140-52, (2014) Haploinsufficiency of peripheral myelin protein 22 (PMP22) causes hereditary neuropathy with liability to pressure palsies, a peripheral nerve lesion induced by minimal trauma or compression. As PMP22 is localized to cholesterol-enriched membrane domains that... |
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An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease.
EMBO Mol. Med. 7(2) , 175-89, (2015) The β-site amyloid precursor protein cleaving enzyme-1 (BACE1), an essential protease for the generation of amyloid-β (Aβ) peptide, is a major drug target for Alzheimer's disease (AD). However, there is a concern that inhibiting BACE1 could also affect severa... |
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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Chem. Res. Toxicol. 23 , 171-83, (2010) Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental drug discovery projects toward safer medicines. In this st... |
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Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
J. Sci. Ind. Res. 65(10) , 808, (2006) Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI types (hepatotoxic side effects) seen in the clinic can be tra... |
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Circuit formation and function in the olfactory bulb of mice with reduced spontaneous afferent activity.
J. Neurosci. 35(1) , 146-60, (2015) The type of neuronal activity required for circuit development is a matter of significant debate. We addressed this issue by analyzing the topographic organization of the olfactory bulb in transgenic mice engineered to have very little afferent spontaneous ac... |
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An RNA binding protein promotes axonal integrity in peripheral neurons by destabilizing REST.
J. Neurosci. 34(50) , 16650-61, (2014) The RE1 Silencing Transcription Factor (REST) acts as a governor of the mature neuronal phenotype by repressing a large consortium of neuronal genes in non-neuronal cells. In the developing nervous system, REST is present in progenitors and downregulated at t... |
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Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Bioorg. Med. Chem. 18 , 2225-31, (2010) There are many of pathogen parasite species with different susceptibility profile to antiparasitic drugs. Unfortunately, almost QSAR models predict the biological activity of drugs against only one parasite species. Consequently, predicting the probability wi... |
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Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
J. Med. Chem. 51 , 6740-51, (2008) The work provides a new model for the prediction of the MAO-A and -B inhibitor activity by the use of combined complex networks and QSAR methodologies. On the basis of the obtained model, we prepared and assayed 33 coumarin derivatives, and the theoretical pr... |