β-Interleukin I (163-171), human
β-Interleukin I (163-171), human结构式
|
常用名 | β-Interleukin I (163-171), human | 英文名 | β-Interleukin I (163-171), human |
|---|---|---|---|---|
| CAS号 | 106021-96-9 | 分子量 | 1004.99000 | |
| 密度 | 1.419g/cm3 | 沸点 | 1682.6ºC at 760mmHg | |
| 分子式 | C39H64N12O19 | 熔点 | N/A | |
| MSDS | N/A | 闪点 | 971.4ºC |
|
Peptide-mediated inhibition of mitogen-activated protein kinase-activated protein kinase-2 ameliorates bleomycin-induced pulmonary fibrosis.
Am. J. Respir. Cell. Mol. Biol. 49(1) , 47-57, (2013) Mitogen-activated protein kinase-activated protein kinase-2 (MAPKAPK2, or MK2), a serine/threonine kinase downstream of p38 mitogen-activated protein kinase, has been implicated in inflammation and fibrosis. Compared with pathologically normal lung tissue, si... |
|
|
Tamoxifen attenuates inflammatory-mediated damage and improves functional outcome after spinal cord injury in rats.
J. Neurochem. 109(6) , 1658-67, (2009) Tamoxifen has been found to be neuroprotective in both transient and permanent experimental ischemic stroke. However, it remains unknown whether this agent shows a similar beneficial effect after spinal cord injury (SCI), and what are its underlying mechanism... |
|
|
Pro- and anti-inflammatory cytokines in chronic pediatric dialysis patients: effect of aspirin.
Clin. J. Am. Soc. Nephrol. 1(5) , 979-86, (2006) Dialysis provides effective and safe treatment of ESRD in children, but patients who are maintained on chronic dialysis are at risk for cardiovascular disease. One major risk factor for cardiovascular disease in adult patients with ESRD is chronic inflammatio... |
|
|
Evidence that MDMA ('ecstasy') increases cannabinoid CB2 receptor expression in microglial cells: role in the neuroinflammatory response in rat brain.
J. Neurochem. 113(1) , 67-78, (2010) 3,4-Methylenedioxymethamphetamine (MDMA, 'ecstasy') produces selective long-lasting serotonergic neurotoxicity in rats. The drug also produces acute hyperthermia which modulates the severity of the neurotoxic response. In addition, MDMA produces signs of neur... |
|
|
Individual isomers of conjugated linoleic acid reduce inflammation associated with established collagen-induced arthritis in DBA/1 mice.
J. Nutr. 140(8) , 1454-61, (2010) Previously, dietary conjugated linoleic acid [(CLA), an equal mixture of cis-9, trans-11 (c9t11) and trans-10, cis-12 (t10c12) CLA isomers], was found to reduce inflammation in the murine collagen antibody-induced arthritis model, but less so in the murine co... |
|
|
T cell-associated CD18 but not CD62L, ICAM-1, or PSGL-1 is required for the induction of chronic colitis.
Am. J. Physiol. Gastrointest. Liver Physiol. 292(6) , G1706-14, (2007) The induction and perpetuation of chronic colitis are thought to involve a complex set of adhesive interactions between T cells and endothelial cells located on the vasculature within secondary lymphoid tissue and the intestine. The objective of this study wa... |
|
|
Delineation of the effects of angiotensin type 1 and 2 receptors on HL-1 cardiomyocyte apoptosis.
Apoptosis 17(8) , 908-15, (2012) Angiotensin II (Ang II) exerts its effects by activating its receptors, primarily type 1 (AT1R) and type 2 (AT2R). While the role of AT1R activation in cardiomyocyte physiology is well known, the role of AT2R in cardiomyocyte apoptosis remains controversial. ... |
|
|
Structural-activity relationship study of highly-functionalized imidazolines as potent inhibitors of nuclear transcription factor-kappaB mediated IL-6 production.
Bioorg. Med. Chem. 17(8) , 3093-103, (2009) We herein describe the synthesis and anti-inflammatory properties of a small library of imidazoline-based NF-kappaB inhibitors. The structure-activity relationship of various substituents on an imidazoline core structure was evaluated for the ability to inhib... |
|
|
Modulation of NADPH oxidase activation in cerebral ischemia/reperfusion injury in rats.
Brain Res. 1372 , 92-102, (2011) NADPH oxidase is a major complex that produces reactive oxygen species (ROSs) during the ischemic period and aggravates brain damage and cell death after ischemic injury. Although many approaches have been tested for preventing production of ROSs by NADPH oxi... |
|
|
Tocilizumab inhibits interleukin-6-mediated matrix metalloproteinase-2 and -9 secretions from human amnion cells in preterm premature rupture of membranes.
Gynecol. Obstet. Invest. 68(3) , 145-53, (2009) In the present study, we investigated the participation of inflammatory cytokine-induced mediated matrix metalloproteinase (MMP) expressions and inhibition of interleukin (IL)-6-induced MMP secretion in amniotic epithelial cells by tocilizumab.To investigate ... |