Zomepirac钠盐
Zomepirac钠盐结构式
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常用名 | Zomepirac钠盐 | 英文名 | Zomepirac (sodium salt) |
|---|---|---|---|---|
| CAS号 | 64092-48-4 | 分子量 | 313.71100 | |
| 密度 | N/A | 沸点 | 470.8ºC at 760 mmHg | |
| 分子式 | C15H13ClNNaO3 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 238.5ºC | |
| 符号 |
GHS06 |
信号词 | Danger |
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Limitations of hepatocytes and liver homogenates in modelling in vivo formation of acyl glucuronide-derived drug-protein adducts.
J. Pharmacol. Toxicol. Methods 41(1) , 27-32, (1999) The covalent binding of drugs or their metabolites to proteins is of increasing interest in the investigation of the toxicity of these compounds. Recent attention on biological consequences of protein adduct formation with carboxylate drugs, derived via their... |
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Regulating the cancer-inducing potential of non-steroidal anti-inflammatory drugs: some lessons from the 1970s and 1980s.
Soc. Sci. Med. 46(1) , 39-51, (1998) This article systematically examines government regulation of medicines in the U.K. and the U.S. with specific reference to carcinogenic risk assessment. By taking four non-steroidal anti-inflammatory drugs (NSAIDs) as case studies, it is argued that there ha... |
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Identification of zomepirac-S-acyl-glutathione in vitro in incubations with rat hepatocytes and in vivo in rat bile.
Drug Metab. Dispos. 31(11) , 1429-36, (2003) Zomepirac (ZP), a nonsteroidal anti-inflammatory drug that was withdrawn from use, is metabolized to zomepirac-1-O-acyl-glucuronide (ZP-1-O-G), a chemically reactive conjugate that has been implicated in the toxicity of the drug. In the present studies, we in... |
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Single dose oral mefenamic acid for acute postoperative pain in adults.
Cochrane Database Syst. Rev. (3) , CD007553, (2011) Mefenamic acid is a non-steroidal anti-inflammatory drug (NSAID). It is most often used for treating pain of dysmenorrhoea in the short term (seven days or less), as well as mild to moderate pain including headache, dental pain, postoperative and postpartum p... |
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Single dose oral fenoprofen for acute postoperative pain in adults.
Cochrane Database Syst. Rev. (2) , CD007556, (2011) Fenoprofen is a non-steroidal anti-inflammatory drug (NSAID), available in several different countries, but not widely used.To assess the efficacy of single dose oral fenoprofen in acute postoperative pain, and associated adverse events.We searched Cochrane C... |
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Synthesis and mass-spectrometric characterization of human serum albumins modified by covalent binding of two non-steroidal anti-inflammatory drugs: tolmetin and zomepirac.
Biochem. J. 311 ( Pt 2) , 431-5, (1995) Human serum albumins modified by covalently bound tolmetin or zomepirac were synthesized as models for similar products formed in vivo from acyl glucuronides. Activated esters of both drugs were prepared with 1-ethyl-3-(3-dimethylaminopropyl)-carbodi-imide, a... |
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Reaction of acyl glucuronides with insulin in vitro: identification of an imine mechanism by electrospray ionization mass spectrometry.
Pharm. Res. 15(2) , 343-6, (1998)
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India ink staining after sodium dodecyl sulfate polyacrylamide gel electrophoresis and in conjunction with Western blots for peptide mapping by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.
Rapid Commun. Mass Spectrom. 16(1) , 35-42, (2002) We present an approach that allows matrix-assisted laser desorption/ionization time-of-flight mass spectrometric (MALDI-TOFMS) peptide mapping of proteins separated by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) and electroblotted ont... |
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Investigating the TNP-OVA and direct popliteal lymph node assays for the detection of immunostimulation by drugs associated with anaphylaxis in humans.
J. Appl. Toxicol. 22(3) , 177-83, (2002) Using current animal models, it is not possible to identify low-molecular-weight compounds (LMWCs) that are likely to be associated with anaphylaxis. It is generally accepted that the ultimate effector mechanism involves drug-induced IgE antibody. The objecti... |
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Photolysis of NSAIDs. IV. Photoproducts of zomepirac determined by LC-ESI-MS.
Biomed. Chromatogr. 18(10) , 820-5, (2004) A sample of 10 mm zomepirac in methanol was photo-irradiated with a Hanovia 200 W high-pressure quartz Hg lamp for 14 days. In total, four photoproducts were observed from the HPLC chromatogram. The preparative HPLC included an YMC-Pack Pro C18 column (250 x ... |