(aS)-N-[(1S)-2-[[(7S)-6,7-二氢-5-甲基-6-氧代-5H-二苯并[b,d]氮杂卓-7-基]氨基]-1-甲基-2-氧代乙基]-3,5-二氟-alpha-羟基苯乙酰胺
![(aS)-N-[(1S)-2-[[(7S)-6,7-二氢-5-甲基-6-氧代-5H-二苯并[b,d]氮杂卓-7-基]氨基]-1-甲基-2-氧代乙基]-3,5-二氟-alpha-羟基苯乙酰胺结构式](https://image.chemsrc.com/caspic/226/209984-57-6.png)
(aS)-N-[(1S)-2-[[(7S)-6,7-二氢-5-甲基-6-氧代-5H-二苯并[b,d]氮杂卓-7-基]氨基]-1-甲基-2-氧代乙基]-3,5-二氟-alpha-羟基苯乙酰胺结构式
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常用名 | (aS)-N-[(1S)-2-[[(7S)-6,7-二氢-5-甲基-6-氧代-5H-二苯并[b,d]氮杂卓-7-基]氨基]-1-甲基-2-氧代乙基]-3,5-二氟-alpha-羟基苯乙酰胺 | 英文名 | LY-411575 |
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| CAS号 | 209984-57-6 | 分子量 | 479.475 | |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | 836.0±65.0 °C at 760 mmHg | |
| 分子式 | C26H23F2N3O4 | 熔点 | 328.47°C | |
| MSDS | 中文版 美版 | 闪点 | 459.4±34.3 °C |
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Targeting both Notch and ErbB-2 signalling pathways is required for prevention of ErbB-2-positive breast tumour recurrence.
Br. J. Cancer 105 , 796-806, (2011) We reported that Notch-1, a potent breast oncogene, is activated in response to trastuzumab and contributes to trastuzumab resistance in vitro. We sought to determine the preclinical benefit of combining a Notch inhibitor (γ-secretase inhibitor (GSI)) and tra... |
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