LY-411575
LY-411575 structure
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Common Name | LY-411575 | ||
|---|---|---|---|---|
| CAS Number | 209984-57-6 | Molecular Weight | 479.475 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 836.0±65.0 °C at 760 mmHg | |
| Molecular Formula | C26H23F2N3O4 | Melting Point | 328.47°C | |
| MSDS | Chinese USA | Flash Point | 459.4±34.3 °C | |
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Targeting both Notch and ErbB-2 signalling pathways is required for prevention of ErbB-2-positive breast tumour recurrence.
Br. J. Cancer 105 , 796-806, (2011) We reported that Notch-1, a potent breast oncogene, is activated in response to trastuzumab and contributes to trastuzumab resistance in vitro. We sought to determine the preclinical benefit of combining a Notch inhibitor (γ-secretase inhibitor (GSI)) and tra... |
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