秦皮素
秦皮素结构式
|
常用名 | 秦皮素 | 英文名 | Fraxetin |
|---|---|---|---|---|
| CAS号 | 574-84-5 | 分子量 | 208.167 | |
| 密度 | 1.5±0.1 g/cm3 | 沸点 | 472.0±45.0 °C at 760 mmHg | |
| 分子式 | C10H8O5 | 熔点 | 230-232°C | |
| MSDS | 中文版 美版 | 闪点 | 196.0±22.2 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
|
[Studies on chemical constituents from stem barks of Fraxinus paxiana].
Zhongguo Zhong Yao Za Zhi 33(16) , 1990-3, (2008) To investigate the chemical constituents of Fraxinus paxiana.The chemical constituents were isolated and purified by chromatographic techniques and the structures of the compounds were identified with or by spectroscopic methods.Fifteen compounds were obtaine... |
|
|
Antihyperglycemic effect of fraxetin on hepatic key enzymes of carbohydrate metabolism in streptozotocin-induced diabetic rats.
Biochimie 95(10) , 1848-54, (2013) Epidemiological studies have demonstrated that the diabetes mellitus is a serious health burden for both governments and healthcare providers. The present study was hypothesized to evaluate the antihyperglycemic potential of fraxetin by determining the activi... |
|
|
[Coumarins from branch of Fraxinus sieboldiana and their antioxidative activity].
Zhongguo Zhong Yao Za Zhi 33(14) , 1708-10, (2008) To investigate the chemical constituents from the branch of Fraxinus sieboldiana, and evaluate their antioxidative activity.The chemical constituents were isolated and purified by chromatographic techniques over silica gel, macroporous adsorbent resin, Sephad... |
|
|
Effect of fraxetin on antioxidant defense and stress proteins in human neuroblastoma cell model of rotenone neurotoxicity. Comparative study with myricetin and N-acetylcysteine.
Toxicol. Appl. Pharmacol. 209(3) , 214-25, (2005) Mitochondrial complex I inhibitor rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production. Recently, it has been shown that fraxetin (coumarin) and myricetin (flavonoid) have significant neuroprotective effects against ap... |
|
|
Effect of fraxetin and myricetin on rotenone-induced cytotoxicity in SH-SY5Y cells: comparison with N-acetylcysteine.
Eur. J. Pharmacol. 472(1-2) , 81-7, (2003) The purpose of this study was to investigate the potential neuroprotective effects of myricetin (flavonoid) and fraxetin (coumarin) on rotenone-induced apoptosis in SH-SY5Y cells, and the possible signal pathway involved in a neuronal cell model of Parkinson'... |
|
|
Neuroprotective effect of fraxetin and myricetin against rotenone-induced apoptosis in neuroblastoma cells.
Brain Res. 1009(1-2) , 9-16, (2004) Rotenone-induced apoptosis is considered to contribute to the etiology of Parkinson's disease (PD). We try to prevent the apoptosis induced by rotenone toxicity with 50 microM myricetin, 100 microM fraxetin and 100 microM N-acetylcysteine (NAC) that protect a... |
|
|
HIV gp41 binding phenolic components from Fraxinus sieboldiana var. angustata.
Planta Med. 68(11) , 1034-6, (2002) By means of HIV gp41 binding affinity directed chromatographic fractionation, three phenylethanoid glycosides; calceolarioside A ( 1), calceolarioside B ( 2) and acteoside ( 3), along with four hydroxycoumarins; esculin ( 4), fraxin ( 5), fraxetin ( 6) and es... |
|
|
Antioxidant activity of Fraxetin: in vivo and ex vivo parameters in normal situation versus induced stress.
Biol. Pharm. Bull. 24(7) , 777-84, (2001) The aim of this paper was to study the influence of Fraxetin (7,8-dihydroxy-6-methoxv coumarin) treatment in a Drosophila melanogaster experimental model, analyzing several parameters in normal situations and instances of induced oxidative stress. Fraxetin tr... |
|
|
Dual anti-oxidative effects of fraxetin isolated from Fraxinus rhinchophylla.
Biol. Pharm. Bull. 32(9) , 1527-32, (2009) Atherosclerosis is main cause of arteriosclerosis. The pivotal role of low-density lipoprotein (LDL) oxidation in atherogenesis suggests antioxidants may help prevent cardiovascular disease. Fraxinus rhynchophylla DENCE (Oleaceae) is a traditional medicinal p... |
|
|
Natural coumarins as a novel class of neuroprotective agents.
Mini Rev. Med. Chem. 9(11) , 1262-71, (2009) Neurodegenerative disorders are a heterogeneous group of diseases and are among the most invaliding syndromes for humans. The aim of this manuscript is to review what has been reported so far in the literature about coumarins as a novel class of pharmacologic... |