21-脱氧皮质醇
21-脱氧皮质醇结构式
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常用名 | 21-脱氧皮质醇 | 英文名 | 11beta,17alpha-dihydroxy-4-pregnene-3,20-dione |
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| CAS号 | 641-77-0 | 分子量 | 346.46100 | |
| 密度 | 1.21g/cm3 | 沸点 | 523.9ºC at 760 mmHg | |
| 分子式 | C21H30O4 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 284.7ºC | |
| 符号 |
GHS02, GHS06, GHS08 |
信号词 | Danger |
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An LC-MS/MS method for steroid profiling during adrenal venous sampling for investigation of primary aldosteronism.
J. Steroid Biochem. Mol. Biol. 145 , 75-84, (2015) Steroid profiling for diagnosis of endocrine disorders featuring disordered production of steroid hormones is now possible from advances in liquid chromatography with tandem mass spectrometry (LC-MS/MS). Adrenal venous (AV) measurements of aldosterone and cor... |
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Hirsutism and acne in women: coordinated radioimmunoassays for eight relevant plasma steroids.
Clin. Chem. 40(12) , 2296-305, (1994) We developed and validated a coordinated set of RIAs for the following eight steroids in single small aliquots (< or = 1 mL) of plasma: androstenedione, dehydroepiandrosterone, 11-deoxycortisol, 21-deoxycortisol (21-DF), 11 beta-hydroxyandrostenedione, 17 alp... |
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Superior discriminating value of ACTH-stimulated serum 21-deoxycortisol in identifying heterozygote carriers for 21-hydroxylase deficiency.
Clin. Endocrinol. (Oxf.) 73(6) , 700-6, (2010) Congenital adrenal hyperplasia caused by classic 21-hydroxylase deficiency (21OHD) is an autosomal recessive disorder with a high prevalence of asymptomatic heterozygote carriers (HTZ) in the general population, making case detection desirable by routine meth... |
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Neonatal screening: identification of children with 11β-hydroxylase deficiency by second-tier testing.
Horm. Res. Paediatr. 77(3) , 195-9, (2012) 21-Hydroxylase deficiency (21-OHD) is the target disease of newborn screening for congenital adrenal hyperplasia (CAH). We describe the additional detection of patients suffering from 11β-hydroxylase deficiency (11-OHD) by second-tier testing.Over a period of... |
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Premature pubarche in Mediterranean girls: high prevalence of heterozygous CYP21 mutation carriers.
Gynecol. Endocrinol. 26(5) , 319-24, (2010) This study investigated the prevalence and consequences of heterozygous CYP21A2 mutations in premature pubarche (PP) girls.We investigated 36 French Mediterranean girls with isolated PP. We performed synacthen testing with 17OHP and 21-deoxycortisol evaluatio... |
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Zona fasciculata 21-hydroxysteroids and precursor-to-product ratios in 21-hydroxylase deficiency: further characterization of classic and non-classic patients and heterozygote carriers.
J. Endocrinol. Invest. 34(8) , 587-92, (2011) Although much is known about the increased levels of the 21-hydroxylase substrates 17-hydroxyprogesterone (17OHP) and 21-deoxycortisol (21DF) - the biochemical markers of all forms of 21-hydroxylase deficiency (21OHD), only limited information is available on... |
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The application of a new highly-sensitive radioimmunoassay for plasma 21-deoxycortisol to the detection of steroid-21-hydroxylase deficiency.
Ann. Clin. Biochem. 31 ( Pt 1) , 56-64, (1994) 21-deoxycortisol (21-DF) is a steroid of strictly adrenal origin formed by the 11-hydroxylation of 17-hydroxyprogesterone. This metabolic pathway is minor in normal subjects, in whom basal plasma concentrations range from 0.03 to 0.63 nmol/L and from 0.865 to... |
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Plasma 21-deoxycortisol: comparison of a time-resolved fluoroimmunoassay using a biotinylated tracer with a radioimmunossay using (125)iodine.
J. Steroid Biochem. Mol. Biol. 72(1-2) , 55-60, (2000) Plasma 21-deoxycortisol (21DF) is an excellent marker of 21-hydroxylase deficiency. Currently, it is the only marker able to detect heterozygous carriers with 21-hydroxylase deficiency after ACTH stimulation. We have already developed radioimmunoassays for 21... |
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Radioimmunoassay of three deoxycorticoids in human plasma following HPLC separation.
Steroids 60(9) , 615-20, (1995) A radioimmunoassay of three deoxycorticoids, namely 11 beta,17 alpha-dihydroxy-4-pregnene-3,20-dione (21-deoxycortisol), 17 alpha,21-dihydroxy-4-pregnene-3,20-dione (11-deoxycortisol), and 21-hydroxy-4-pregnene-3,20-dione (11-deoxycorticosterone) which are im... |
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Diagnosis of adrenal cortical dysfunction by liquid chromatography-tandem mass spectrometry.
Ann. Clin. Lab. Sci. 31(2) , 199-204, (2001) Liquid chromatography-tandem mass spectrometry (LC-MS/MS) was used to measure 6 metabolic compounds of the adrenocorticosteroid pathway simultaneously on residual specimens from patients who had previously been previously diagnosed, on the basis of immunoassa... |