2-亚氨基-1-咪唑啉乙酸
2-亚氨基-1-咪唑啉乙酸结构式
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常用名 | 2-亚氨基-1-咪唑啉乙酸 | 英文名 | (2-Iminoimidazolidin-1-yl)acetic acid |
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| CAS号 | 35404-50-3 | 分子量 | 143.144 | |
| 密度 | 1.6±0.1 g/cm3 | 沸点 | 278.4±42.0 °C at 760 mmHg | |
| 分子式 | C5H9N3O2 | 熔点 | 25-28 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 122.2±27.9 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Synergistic action of dendritic mitochondria and creatine kinase maintains ATP homeostasis and actin dynamics in growing neuronal dendrites.
J. Neurosci. 35(14) , 5707-23, (2015) The distribution of mitochondria within mature, differentiated neurons is clearly adapted to their regional physiological needs and can be perturbed under various pathological conditions, but the function of mitochondria in developing neurons has been less we... |
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Pharmacological identification of a guanidine-containing β-alanine analogue with low micromolar potency and selectivity for the betaine/GABA transporter 1 (BGT1).
Neurochem. Res. 39(10) , 1988-96, (2014) The γ-aminobutyric acid (GABA) transporters (GATs) are key membrane transporter proteins involved in the termination of GABAergic signaling at synapses in the mammalian brain and proposed drug targets in neurological disorders such as epilepsy. To date, four ... |
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Cyclocreatine inhibits stimulated motility in tumor cells possessing creatine kinase.
Int. J. Cancer 78(1) , 46-52, (1998) Cyclocreatine (1-carboxymethyl-2-iminoimidazolidine), an analog of creatine and a substrate for creatine kinase (EC 2.7.3.2), inhibits the stimulated motility of tumor cells which possess creatine kinase. A2058-055 human melanoma cells, transfected with a cre... |
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Differential effects of creatine kinase isoenzymes and substrates on regeneration in livers of transgenic mice.
Am. J. Physiol. 273(2 Pt 1) , C741-6, (1997) Creatine kinase (CK) has been implicated in affecting cell growth, and the CK substrates creatine (Cr) and cyclocreatine (CyCr) have been shown to have anti-tumor activity. The influence of Cr and CyCr on liver regeneration following major hepatectomy was eva... |
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Critical role of phosphagens in the energy cascade of cutaneous ischemia and protective action of phosphocreatine analogues in skin flap survival.
Plast. Reconstr. Surg. 101(6) , 1597-603, (1998) A general understanding of the pivotal role of phosphocreatine (PCr) as the principal determinant of skin flap survival is now emerging. Definitive metabolic investigations using phosphorus (31P) and proton (1H) magnetic resonance spectroscopy (MRS) have esta... |
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Mutagenesis of two acidic active site residues in human muscle creatine kinase: implications for the catalytic mechanism.
Biochemistry 40(10) , 3056-61, (2001) Creatine kinase (CK) catalyzes the reversible phosphorylation of the guanidine substrate, creatine, by MgATP. Although several X-ray crystal structures of various isoforms of creatine kinase have been published, the detailed catalytic mechanism remains unreso... |
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Isoleucine 69 and valine 325 form a specificity pocket in human muscle creatine kinase.
Biochemistry 43(43) , 13766-74, (2004) Creatine kinase (CK) catalyzes the reversible phosphorylation of creatine by ATP. From a structural perspective, the enzyme utilizes two flexible loop regions to sequester and position the substrates for catalysis. There has been debate over the specific role... |
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Cyclocreatine transport and cytotoxicity in rat glioma and human ovarian carcinoma cells: 31P-NMR spectroscopy.
Am. J. Physiol. 270(1 Pt 1) , C160-9, (1996) Cyclocreatine (CY), an analogue of creatine, inhibits tumor growth in vivo and proliferation of tumor cells in vitro. The goal of this study was to probe the mechanism of CY transport and cytotoxicity in C6 rat glioma cells and OC238 human ovarian carcinoma c... |
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Effects of creatine and cyclocreatine supplementation on kainate induced injury in pre-pubescent rats.
Brain Inj. 18(12) , 1229-41, (2004) To investigate if energy precursor supplementation is neuroprotective in two neuroexcitotoxicity models; the kainate and the kainate followed by chronic phenobarbital models.Rats in experiment 1 received 1% creatine or cyclocreatine chow from age (P) 21-65 da... |
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Kinetics of cyclocreatine and Na(+) cotransport in human breast cancer cells: mechanism of activity.
Am. J. Physiol. 277(4 Pt 1) , C708-16, (1999) The growth-inhibitory effect of cyclocreatine (CCr) and the kinetics of CCr and Na(+) cotransport were investigated in MCF7 human breast cancer cells and its adriamycin-resistant subline with use of (31)P- and (23)Na-NMR spectroscopy. The growth-inhibitory ef... |