[D-p-Cl-Phe6,Leu17]-VIP
![[D-p-Cl-Phe6,Leu17]-VIP结构式](https://image.chemsrc.com/caspic/187/102805-45-8.png)
[D-p-Cl-Phe6,Leu17]-VIP结构式
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常用名 | [D-p-Cl-Phe6,Leu17]-VIP | 英文名 | (p-Chloro-D-Phe6,Leu17)-VIP (human, mouse, rat) trifluoroacetate salt |
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| CAS号 | 102805-45-8 | 分子量 | 3342.204 | |
| 密度 | 1.5±0.1 g/cm3 | 沸点 | N/A | |
| 分子式 | C148H239ClN44O42 | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | N/A |
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Vasoactive intestinal polypeptide antagonists attenuate vagally induced tachycardia in the anesthetized dog.
Am. J. Physiol. 269(4 Pt 2) , H1467-72, (1995) We used three vasoactive intestinal polypeptide (VIP) antagonists, VIP-(10-28), [p-Cl-D-Phe6,Leu17]VIP, and NT-VIP, to evaluate the role of VIP as a mediator of vagally induced tachycardia in chloralose-anesthetized dogs. After we administered muscarinic and ... |
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Pituitary adenylate cyclase-activating peptide stimulates cyclic AMP accumulation in UMR 106 osteoblast-like cells.
J. Endocrinol. 149 , 287, (1996) Pituitary adenylate cyclase-activating peptide (PACAP) and vasoactive intestinal peptide (VIP) share 68% homology and function as neurotransmitters or neuroendocrine factors. Although VIP immunoreactivity has been detected in bone cells, the presence of PACAP... |
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Vagal nerve stimulation increases right ventricular contraction and relaxation and heart rate.
Cardiovasc. Res. 32(5) , 846-53, (1996) To determine the effects of vasoactive intestinal peptide, released from the right and left vagal nerves, on ventricular contraction, relaxation, and heart rate.The muscarinic and beta-adrenergic receptors were blocked with atropine and propranolol, and after... |
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Homeostatic and therapeutic roles of VIP in smooth muscle function: myo-neuroimmune interactions.
Am. J. Physiol. Gastrointest. Liver Physiol. 297(4) , G716-25, (2009) We tested the hypothesis that spontaneous release of vasoactive intestinal peptide (VIP) from enteric neurons maintains homeostasis in smooth muscle function in mild inflammatory insults and that infusion of exogenous VIP has therapeutic effects on colonic sm... |
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Enhancement by atropine of the pancreatic exocrine secretions evoked by vagal stimulation in the pithed rat.
J. Physiol. 469 , 443-57, (1993) 1. Pancreatic secretions were collected in response to 15 min periods of bilateral stimulation of the cervical vagus nerves in the pithed rat. 2. The weight of juice, total HCO3- and total protein evoked by a second period of vagal stimulation were essentiall... |
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The effects of PACAP and VIP on guinea pig tracheal smooth muscle in vitro.
Peptides 15(7) , 1237-41, (1994) Neither pituitary adenylate cyclase activating polypeptide-38 (PACAP) nor its homologue, vasoactive intestinal polypeptide (VIP), contracted guinea pig isolated trachea (GPT), but on preparations contracted with KCl (40 mM), both caused concentration-related ... |
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Effect of vasoactive intestinal peptide on pulmonary surfactants phospholipid synthesis in lung explants.
Acta Pharmacol. Sin. 25(12) , 1652-8, (2004) To investigate the effect of vasoactive intestinal peptide (VIP) on pulmonary surfactants (PS) phospholipid synthesis in cultured lung explants.Lung explants were cultured with serum-free medium, [methyl-3H]choline incorporation, total phospholipid, phosphati... |
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C-type natriuretic peptide applied to the brain enhances exocrine pancreatic secretion through a vagal pathway.
Eur. J. Pharmacol. 524(1-3) , 67-74, (2005) C-type natriuretic peptide (CNP) is the major natriuretic peptide in the brain and its mRNA has been reported in the central nervous system, which supports local synthesis and its role as a neuromodulator. The aim of the present work was to study the effect o... |
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Elevation of intracellular cAMP by noradrenaline and vasoactive intestinal peptide in striated ducts isolated from the rabbit mandibular salivary gland.
Arch. Oral Biol. 41(7) , 689-94, (1996) Salivary gland intralobular ducts are responsible for the modification of the electrolyte composition of the primary fluid secreted by the acini. However, the intracellular messengers that regulate this and other intralobular duct cell processes have not been... |
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Characterization of VIP receptor-effector system antagonists in rat and mouse peritoneal macrophages.
Eur. J. Pharmacol. 321(3) , 379-86, (1997) In the present study we show that the synthetic peptides [4-Cl-D-Phe6,Leu17]VIP and the growth hormone releasing factor (GRF) analog [Ac-Tyr1,D-Phe2]GRF-(1-29)-NH2 inhibit in a competitive manner the specific [125I]VIP binding to both rat and mouse peritoneal... |