(p-Chloro-D-Phe6,Leu17)-VIP (human, mouse, rat) trifluoroacetate salt
(p-Chloro-D-Phe6,Leu17)-VIP (human, mouse, rat) trifluoroacetate salt structure
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Common Name | (p-Chloro-D-Phe6,Leu17)-VIP (human, mouse, rat) trifluoroacetate salt | ||
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| CAS Number | 102805-45-8 | Molecular Weight | 3342.204 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C148H239ClN44O42 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
Use of (p-Chloro-D-Phe6,Leu17)-VIP (human, mouse, rat) trifluoroacetate salt[D-p-Cl-Phe6,Leu17]-VIP is a competitive and selective antagonist of vasoactive intestinal peptide (VIP) receptor, with the IC50 of 125.8 nM. [D-p-Cl-Phe6,Leu17]-VIP has no activity on glucagon, secretin or GRF receptors[1][2][3]. |
| Name | L-Histidyl-L-seryl-L-α-aspartyl-L-alanyl-L-valyl-4-chloro-D-phenylalanyl-L-threonyl-L-α-aspartyl-L-asparaginyl-L-tyrosyl-L-threonyl-L-arginyl-L-leucyl-L-arginyl-L-lysyl-L-glutaminyl-L-leucyl-L-alanyl-L-valyl-L-lysyl-L-lysyl-L-tyrosyl-L-leucyl-L-asparaginyl-L-seryl-L-isoleucyl-L-leucyl-L-aspartamide |
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| Synonym | More Synonyms |
| Description | [D-p-Cl-Phe6,Leu17]-VIP is a competitive and selective antagonist of vasoactive intestinal peptide (VIP) receptor, with the IC50 of 125.8 nM. [D-p-Cl-Phe6,Leu17]-VIP has no activity on glucagon, secretin or GRF receptors[1][2][3]. |
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| Related Catalog | |
| Target |
IC50: 125.8 nM (VIP receptor)[1] |
| References |
| Density | 1.5±0.1 g/cm3 |
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| Molecular Formula | C148H239ClN44O42 |
| Molecular Weight | 3342.204 |
| Exact Mass | 3339.760742 |
| PSA | 1453.69000 |
| LogP | -4.01 |
| Index of Refraction | 1.657 |
| Storage condition | -20°C |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
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Vasoactive intestinal polypeptide antagonists attenuate vagally induced tachycardia in the anesthetized dog.
Am. J. Physiol. 269(4 Pt 2) , H1467-72, (1995) We used three vasoactive intestinal polypeptide (VIP) antagonists, VIP-(10-28), [p-Cl-D-Phe6,Leu17]VIP, and NT-VIP, to evaluate the role of VIP as a mediator of vagally induced tachycardia in chloralo... |
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Pituitary adenylate cyclase-activating peptide stimulates cyclic AMP accumulation in UMR 106 osteoblast-like cells.
J. Endocrinol. 149 , 287, (1996) Pituitary adenylate cyclase-activating peptide (PACAP) and vasoactive intestinal peptide (VIP) share 68% homology and function as neurotransmitters or neuroendocrine factors. Although VIP immunoreacti... |
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Vagal nerve stimulation increases right ventricular contraction and relaxation and heart rate.
Cardiovasc. Res. 32(5) , 846-53, (1996) To determine the effects of vasoactive intestinal peptide, released from the right and left vagal nerves, on ventricular contraction, relaxation, and heart rate.The muscarinic and beta-adrenergic rece... |
| L-Aspartamide, L-histidyl-L-seryl-L-α-aspartyl-L-alanyl-L-valyl-4-chloro-D-phenylalanyl-L-threonyl-L-α-aspartyl-L-asparaginyl-L-tyrosyl-L-threonyl-L-arginyl-L-leucyl-L-arginyl-L-lysyl-L-glutam inyl-L-leucyl-L-alanyl-L-valyl-L-lysyl-L-lysyl-L-tyrosyl-L-leucyl-L-asparaginyl-L-seryl-L-isoleucyl-L-leucyl- |
| L-Histidyl-L-seryl-L-α-aspartyl-L-alanyl-L-valyl-4-chloro-D-phenylalanyl-L-threonyl-L-α-aspartyl-L-asparaginyl-L-tyrosyl-L-threonyl-L-arginyl-L-leucyl-L-arginyl-L-lysyl-L-glutaminyl-L-leucyl-L -alanyl-L-valyl-L-lysyl-L-lysyl-L-tyrosyl-L-leucyl-L-asparaginyl-L-seryl-L-isoleucyl-L-leucyl-L-aspartamide |
| 6-(4-Chloro-D-Phenylalanine)-17-L-Leucine-Vasoactive Intestinaloctacosapeptide (Swine) |
| (p-Chloro-D-Phe6,Leu17)-VIP |
| [4ClDPhe6,Leu17] VIP |