2-巯基烟酸
2-巯基烟酸结构式
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常用名 | 2-巯基烟酸 | 英文名 | 2-MERCAPTONICOTINIC ACID |
|---|---|---|---|---|
| CAS号 | 38521-46-9 | 分子量 | 155.174 | |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | 337.6±27.0 °C at 760 mmHg | |
| 分子式 | C6H5NO2S | 熔点 | 263-265 °C(lit.) | |
| MSDS | 美版 | 闪点 | 158.0±23.7 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Preactivated thiolated poly(methacrylic acid-co-ethyl acrylate): synthesis and evaluation of mucoadhesive potential.
Eur. J. Pharm. Sci. 63 , 132-9, (2014) The study was aimed to developed and investigate a novel polymer for intestinal drug delivery with improved mucoadhesive properties. Therefore Eudragit® L 100-55 (poly(methacrylic acid-co-ethyl acrylate)) was thiolated by covalent attachment of L-cysteine. Th... |
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Development and in vitro evaluation of a buccal drug delivery system based on preactivated thiolated pectin.
Drug Dev. Ind. Pharm. 40(11) , 1530-7, (2014) The aim of this study was to evaluate the potential of preactivated thiolated pectin (Pec-Cys-MNA) for buccal drug delivery. Therefore, a gel formulation containing this novel polymer and the model drug lidocaine was prepared and investigated in vitro in term... |
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Next generation of buccadhesive excipient: Preactivated carboxymethyl cellulose.
Int. J. Pharm. 500 , 120-7, (2016) Assessment of preactivated carboxymethyl cellulose as potential excipient for buccal drug delivery.Firstly, carboxymethyl cellulose (CMC) and cysteine (SH) were covalently coupled via amide bond formation to obtain thiolated carboxymethyl cellulose (CMC-SH). ... |
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An in-vitro exploration of permeation enhancement by novel polysulfonate thiomers.
Int. J. Pharm. 496 , 304-13, (2015) The study was aimed to synthesize preactivated polysulfonate thiomers using poly(4-styrenesulfonic acid-co-maleic acid) (PSSA-MA) and to evaluate their permeation enhancing properties. PSSA-MA-cysteamine (PC) conjugates with 2-mercaptonicotinic acid (2MNA) ha... |
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Preactivated thiolated nanoparticles: A novel mucoadhesive dosage form.
Int. J. Pharm. 497 , 123-8, (2016) Within this study a novel form of mucoadhesive nanoparticles (NPs) exhibiting a prolonged residence time on mucosal tissues was developed. In order to achieve this goal a new thiomer was synthesized by the covalent attachment of the amino acid l-cysteine ethy... |
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Thiolated and S-protected hydrophobically modified cross-linked poly(acrylic acid)--a new generation of multifunctional polymers.
Eur. J. Pharm. Biopharm. 88(2) , 390-6, (2014) The aim of this study was to create a novel multifunctional polymer by covalent attachment of l-cysteine to the polymeric backbone of hydrophobically modified cross-linked poly(acrylic acid) (AC1030). Secondly, the free thiol groups of the resulting thiomer w... |
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The efficient and specific isolation of the antibodies from human serum by thiophilic paramagnetic polymer nanospheres.
Biotechnol. Prog. 25(2) , 376-83, (2009) A rapid and effective method to specifically isolate the antibodies from human serum was presented based on the fast magnetic separation and specific adsorption of the novel thiophilic magnetic polymer nanospheres, which were synthesized by using miniemulsion... |
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Anticancer and cytotoxic effects of a triorganotin compound with 2-mercapto-nicotinic acid in malignant cell lines and tumor bearing Wistar rats.
Eur. J. Pharm. Sci. 42(3) , 253-61, (2011) Nowadays, investigation for possible therapeutic applications of various metal-based drugs attracts the scientific interest worldwide. The triorganotin compound bis[triphenyltin(IV)](3-carboxy-pyridine-2-thionato) (SnMNA), was tested for its anti-proliferativ... |
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Inhibition of glucose-6-phosphate phosphohydrolase by 3-mercaptopicolinate and two analogs is metabolically directive.
Biochem. Cell Biol. 71(3-4) , 113-21, (1993) 3-Mercaptopicolinae (3-MP) blocks gluconeogenesis from lactate, pyruvate, alanine, and other substrates through its inhibition of phosphoenolpyruvate carboxykinase. Nevertheless, we observed increased glycogenesis, net glucose uptake, and glucose-6-P levels i... |
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Poly[[diaquabis(μ(2)-4,4'-bipyridyl)iron(II)] bis{2-[(3-carboxypyridin-2-yl)disulfanyl]nicotinate}].
Acta Crystallogr. Sect. E Struct. Rep. Online 68(Pt 1) , m28, (2012) In the title compound, {[Fe(C(10)H(8)N(2))(2)(H(2)O)(2)](C(12)H(7)N(2)O(4)S(2))(2)}(n), synthesized by hydro-thermal reaction, the 4,4'-bipyridyl ligands (one with symmetry 2, one with symmetry [Formula: see text]) connect Fe(2+) cations, forming a cationic l... |