N,N'-六亚甲基双乙酰胺
N,N'-六亚甲基双乙酰胺结构式
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常用名 | N,N'-六亚甲基双乙酰胺 | 英文名 | Hexamethylene bisacetamide |
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| CAS号 | 3073-59-4 | 分子量 | 200.28 | |
| 密度 | 0.974 g/cm3 | 沸点 | 456.7ºC at 760 mmHg | |
| 分子式 | C10H20N2O2 | 熔点 | 128-129 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 193.2ºC |
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Balancing polymer hydrophobicity for ligand presentation and siRNA delivery in dual function CXCR4 inhibiting polyplexes.
Biomater. Sci. 3 , 1114-23, (2015) In the present study, a series of copolymers (PAMD-Ch) was synthesized by grafting polymeric Plerixafor/AMD3100 (PAMD) with different amounts of cholesterol and the effect of cholesterol modification on siRNA delivery was investigated. PAMD-Ch/siRNA polyplexe... |
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Thioredoxin-interacting protein regulates the differentiation of murine erythroid precursors.
Exp. Hematol. 43 , 393-403.e2, (2015) Thioredoxin-interacting protein (TXNIP) is involved in various cellular processes including redox control, metabolism, differentiation, growth, and apoptosis. With respect to hematopoiesis, TXNIP has been shown to play roles in natural killer cells, dendritic... |
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Cellular Protein WDR11 Interacts with Specific Herpes Simplex Virus Proteins at the trans-Golgi Network To Promote Virus Replication.
J. Virol. 89 , 9841-52, (2015) It has recently been proposed that the herpes simplex virus (HSV) protein ICP0 has cytoplasmic roles in blocking antiviral signaling and in promoting viral replication in addition to its well-known proteasome-dependent functions in the nucleus. However, the m... |
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Genetic manipulation of RPS5 gene expression modulates the initiation of commitment of MEL cells to erythroid maturation: Implications in understanding ribosomopathies.
Int. J. Oncol. 47 , 303-14, (2015) Impairment of ribosome biogenesis contributes to the molecular pathophysiology of ribosomopathies by deregulating cell-lineage specific proliferation, differentiation and apoptosis decisions of haematopoietic progenitor cells. Here, using pro-erythroblast-lik... |
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Acute hypoxia affects P-TEFb through HDAC3 and HEXIM1-dependent mechanism to promote gene-specific transcriptional repression.
Nucleic Acids Res. 42(14) , 8954-69, (2014) Hypoxia is associated with a variety of physiological and pathological conditions and elicits specific transcriptional responses. The elongation competence of RNA Polymerase II is regulated by the positive transcription elongation factor b (P-TEFb)-dependent ... |
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Regulatory role of nucleophosmin during the differentiation of human liver cancer cells.
Int. J. Oncol. 45(1) , 264-72, (2014) Nucleophosmin (NPM, also known as B23), mainly localized in the nucleolus, has been reported to be overexpressed in many types of human cancer, including colon, ovarian, prostate and gastric cancer. NPM was identified while screening the differential nuclear ... |
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Discordant varicella-zoster virus glycoprotein C expression and localization between cultured cells and human skin vesicles.
Virology 382(2) , 171-81, (2008) Because of its very low titer, varicella-zoster virus (VZV) infectivity is usually transferred by passage of trypsin dispersed infected cells. Previously, we observed that gC biosynthesis was markedly delayed in monolayers inoculated with cell free virus. In ... |
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Aberrant expression of nuclear matrix proteins during HMBA-induced differentiation of gastric cancer cells.
World J. Gastroenterol. 16(17) , 2176-82, (2010) To investigate the aberrant expression of nuclear matrix proteins in human gastric cancer cells before and after hexamethylene bisacetamide (HMBA) treatment.Proteomics analysis of differential nuclear matrix proteins was performed by two dimensional electroph... |
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Hexamethylene bisacetamide can convert nonpermissive human cells to a permissive state for expressing the major immediate-early genes of human cytomegalovirus by up-regulating NF-κB activity
Virology 383(2) , 195-206, (2009) Expression of the major immediate-early (MIE) genes of human cytomegalovirus (HCMV) in the human thyroid papillary carcinoma cell line TPC-1 is repressed at the transcriptional level. However, treatment of these cells with hexamethylene bisacetamide (HMBA), a... |
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Hexamethylene bisacetamide leads to reduced helper virus-free HSV-1 amplicon expression titers via suppression of ICP0.
J. Gene Med. 10(2) , 152-64, (2008) The herpes simplex virus (HSV)-derived amplicon vector has evolved into a promising gene transfer platform for widespread DNA delivery in gene replacement strategies and vaccine development given its ease of molecular manipulation, large transgene capacity, a... |